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Titolo:
alpha 7-containing nicotinic receptors are segregated to the somatodendritic membrane of the cholinergic neurons in the avian nucleus semilunaris
Autore:
Sorenson, EM; El-Bogdadi, DG; Nong, Y; Chiappinelli, VA;
Indirizzi:
George Washington Univ, Med Ctr, Dept Pharmacol, Washington, DC 20037 USA George Washington Univ Washington DC USA 20037 , Washington, DC 20037 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 541 - 550
SICI:
0306-4522(2001)103:2<541:A7NRAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL SPIRIFORM NUCLEUS; IMMUNOHISTOCHEMICAL LOCALIZATION; ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; MONOCLONAL-ANTIBODIES; ACETYLTRANSFERASE; MESENCEPHALON; INTERNEURONS; DIVERSITY; TECTUM;
Keywords:
choline acetyltransferase; autoreceptors; neurotransmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sorenson, EM George Washington Univ, Med Ctr, Dept Pharmacol, 2300 Eye St NW, Washington, DC 20037 USA George Washington Univ 2300 Eye St NW Washington DC USA 20037
Citazione:
E.M. Sorenson et al., "alpha 7-containing nicotinic receptors are segregated to the somatodendritic membrane of the cholinergic neurons in the avian nucleus semilunaris", NEUROSCIENC, 103(2), 2001, pp. 541-550

Abstract

Segregation of ion channels and neurotransmitter receptors is an importantmechanism for determining the functionality of the nervous system. In the case of nicotinic acetylcholine receptors, electrophysiological and anatomical studies have demonstrated that these receptors can be located at the somatodendritic and the axon terminal portions of neurons. Functionally, somatodendritic nicotinic receptors mediate fast excitatory transmission and possibly regulate other cell functions, while presynaptic nicotinic receptorsenhance the release of neurotransmitters from axon terminals. Neurons in the mesencephalic lateral spiriform nucleus of the chick do not appear to restrict the localization of nicotinic receptors to specific membrane compartments, since receptors containing alpha5 and/or beta2 subunits are found both on the cell bodies and on the axonal projections of these neurons [Torrao A. S. et al. (1996) Brain Res. 743, 154-161]. We report here that, in contrast to lateral spiriform neurons, neurons in the nucleus semilunaris do appear to compartmentalize nicotinic receptors. The cholinergic nucleus semilunaris neurons express a high density of alpha7-containing nicotinic receptors on their somas [Britto L. R. G. et al. (1992) J. comp. Neurol. 317, 325-340]. However, when we examined the projections of these neurons in the lateral spiriform nucleus, we found no evidence for expression of alpha7-containing receptors on the cholinergic fibers from nucleus semilunaris neurons. Furthermore, patch-clamp electrophysiological recording from lateral spiriform neurons indicated an absence of presynaptic alpha7-containing nicotinic receptors capable of modulating the release of acetylcholine. We conclude that neurons are capable of segregating alpha7-containing nicotinic receptors to specific areas of their plasma membrane. Such targeting of nicotinic receptors would play an important role in determining their functional role in neurons. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:38:25