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Titolo:
Nitric oxide in the afferent synaptic transmission of the axolotl vestibular system
Autore:
Flores, A; Soto, E; Vega, R;
Indirizzi:
Univ Autonoma Puebla, Inst Fisiol, Puebla 72000, Mexico Univ Autonoma Puebla Puebla Mexico 72000 st Fisiol, Puebla 72000, Mexico
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 457 - 464
SICI:
0306-4522(2001)103:2<457:NOITAS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GUANYLATE-CYCLASE; HAIR-CELLS; TRANSDUCTION MECHANISM; INNER-EAR; SYNTHASE; NEUROTRANSMITTER; HISTOCHEMISTRY; POTENTIATION; ACTIVATION;
Keywords:
semicircular canal; hair cells; sensory coding; nitric oxide synthase inhibitors; nitric oxide donors; amphibian;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Flores, A Univ Autonoma Puebla, Inst Fisiol, Apartado Postal 406, Puebla 72000, Mexico Univ Autonoma Puebla Apartado Postal 406 Puebla Mexico 72000 co
Citazione:
A. Flores et al., "Nitric oxide in the afferent synaptic transmission of the axolotl vestibular system", NEUROSCIENC, 103(2), 2001, pp. 457-464

Abstract

This study was performed using intracellular and multiunit extracellular recording techniques in order to characterize the role of nitric oxide in the afferent synaptic transmission of the vestibular system of the axolotl (Ambystoma tigrinum). Bath application of nitric oxide synthase inhibitors N-G-nitro-L-arginine (0.01 muM to 10 muM) and N-nitro-L-arginine methyl esterhydrochloride (0.1 muM to 1000 muM) elicited a dose-dependent decrease in the basal discharge of the semicircular canal afferent fibers. NG Nitro-L-arginine also diminished the response to mechanical stimuli. Moreover, NG-nitro-L-arginine (1 muM) produced a hyperpolarization associated with a decrease in the spike discharge and diminished the frequency of the excitatory postsynaptic potentials on afferent fibers recorded intracellularly. Nitric oxide donors were also tested: (i) S-nitroso-N-acetyl-DL-penicillamine (0.1muM to 100 muM) increased the basal discharge and the response to mechanical stimuli. At the maximum effective concentration (100 muM) this drug affected neither the amplitude nor the frequency of the excitatory postsynapticpotentials. However, it slightly depolarized the afferent neurons and decreased their input resistance. (ii) 3-Morpholino-sydnonimine hydrochloride did not significantly affect the basal discharge or the mechanically evoked peak response of afferent neurons at any of the concentrations used (1 muM to 1000 muM). However, after 10 min of perfusion in the bath, 1 muM and 10 muM 3-morpholino-sydnonimine hydrochloride significantly modified the baseline of the mechanically evoked response, producing an increase in the mean spike discharge of the afferent fibers. These results indicate that nitric oxide may have a facilitatory role on the basal discharge and on the response to mechanical stimuli of the vestibular afferent fibers. Thus, nitric oxide probably participates in the sensory coding and adaptative changes of vestibular input in normal and pathological conditions. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:50:40