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Titolo:
Expression of messenger RNAs for glutamic acid decarboxylase,preprotachykinin,cholecystokinin, somatostatin, proenkephalin and neuropeptide Y in the adult rat superior colliculus
Autore:
Harvey, AR; Heavens, RP; Yellachich, LA; Sirinathsinghji, DJS;
Indirizzi:
Univ Western Australia, Dept Anat & Human Biol, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Univ Western Australia, Dept Psychiat & Behav Sci, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Merck Sharp & Dohme Ltd, Res Labs, Ctr Res Neurosci, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Harlow Essex England CM20 2QR 2QR, Essex, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 443 - 455
SICI:
0306-4522(2001)103:2<443:EOMRFG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; LATERAL GENICULATE-NUCLEUS; PARVALBUMIN-IMMUNOREACTIVE NEURONS; ENKEPHALIN-LIKE IMMUNOREACTIVITY; SUPERFICIAL GRAY LAYER; SUBSTANCE-P-LIKE; INSITU HYBRIDIZATION; BRAIN-STEM; ADENOSINE-DEAMINASE; GENE-EXPRESSION;
Keywords:
rat visual system; tectum; neuropeptides; neurochemistry; GABA; visual reflexes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Harvey, AR Univ Western Australia, Dept Anat & Human Biol, Perth, WA 6009,Australia Univ Western Australia Perth WA Australia 6009 6009, Australia
Citazione:
A.R. Harvey et al., "Expression of messenger RNAs for glutamic acid decarboxylase,preprotachykinin,cholecystokinin, somatostatin, proenkephalin and neuropeptide Y in the adult rat superior colliculus", NEUROSCIENC, 103(2), 2001, pp. 443-455

Abstract

The mammalian superior colliculus is an important subcortical integrator of sensorimotor behaviours. It is multi-layered, each layer containing specific neuronal types and possessing distinct input/output relationships. Herewe use in situ hybridisation methods to map the distribution of seven neurotransmitters/neuromodulator systems in adult rat superior colliculus. Coronal sections were probed for preprotachykinin, cholecystokinin, somatostatin, proenkephalin, neuropeptide Y and the enzymes glutamic acid decarboxylase and choline acetyltransferase, markers for GABA and acetylcholine respectively. Cells expressing glutamic acid decarboxylase messenger RNA were the most abundant, the highest density being found in the superficial layers. Many cells containing proprotachykinin messenger RNA were found in stratum zonale and the upper two-thirds of stratum griseum superficiale; cells were also located in deeper tectal laminae, particularly caudomedially. Most cholecystokinin messenger RNA expressing cells were located in the superficiallayers with a prominent band in the middle third of stratum griseum superficiale. Cells expressing moderate to high levels of somatostatin messenger RNA formed a dense band in the lower third of stratum griseum superficiale/upper stratum opticum; two less distinct tiers of labelling were seen in deeper layers. These in situ hybridisation data reveal three distinct sublaminae in rat stratum griseum superficiale. Cells expressing moderate to low levels of proenkephalin messenger RNA were located in lower stratum griseum superficiale/upper stratum opticum and intermediate laminae. A cluster of enkephalinergic cells was located medially in the deep tectal laminae. Expression of neuropeptide Y messenger RNA was relatively low and mostly confined to cells in stratum griseum superficiale and stratum opticum. No choline acetyltransferase messenger RNA was detected. This in situ analysis of seven different neurotransmitters/neuromodulator systems sheds new Light on the neurochemical organisation of the rat superior colliculus. The data are related to what is known anatomically and physiologically about intrinsic and extrinsic tectal circuitry, and the potential involvement of different neuropeptides in these circuits is discussed. The work forms the basis for future developmental studies examining the effects of transplantation and visual deprivation/ deafferentation on tectal neurochemistry and function. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:16:10