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Titolo:
Cholinergic neurons expressing neuromedin K receptor (NK3) in the basal forebrain of the rat: A double immunofluorescence study
Autore:
Chen, LW; Wei, LC; Liu, HL; Ding, YQ; Zhang, H; Rao, ZR; Ju, G; Chan, YS;
Indirizzi:
Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, Xijing Hosp, Dept Radiotherapy, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 413 - 422
SICI:
0306-4522(2001)103:2<413:CNENKR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ENDOGENOUS ACETYLCHOLINE-RELEASE; TACHYKININ BINDING-SITES; IN-VIVO MICRODIALYSIS; SUBSTANCE-P RECEPTOR; NEUROKININ-B; ALZHEIMERS-DISEASE; INSITU HYBRIDIZATION; MESSENGER-RNAS; SPINAL-CORD;
Keywords:
choline acetyltransferase; neuromedin K receptor; co-localization; immunocytochemistry; forebrain; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, LW Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 Peoples R China
Citazione:
L.W. Chen et al., "Cholinergic neurons expressing neuromedin K receptor (NK3) in the basal forebrain of the rat: A double immunofluorescence study", NEUROSCIENC, 103(2), 2001, pp. 413-422

Abstract

By using a double immunofluorescence method we have examined the distribution of cholinergic neurons expressing neuromedin K receptor (NK3) in the rat brain and spinal cord. The distribution of neuromedin K receptor-like immunoreactive neurons completely overlapped with that of choline acetyltransferase-positive neurons in certain regions of the basal forebrain, e.g. the medial septal nucleus, nucleus of the diagonal band of Broca, magnocellularpreoptic nucleus and substantia innominata. Partially overlapping distributions of neuromedin K receptor-like immunoreactive and choline acetyltransferase-positive neurons were found in the basal nucleus of Meynert, globus pallidus, ventral pallidum of the forebrain, tegmental nuclei of the pens and dorsal motor nucleus of the vagus. Neurons showing both neuromedin K receptor-like and choline acetyltransferase immunoreactivities, however, were found predominantly in the medial septal nucleus, nucleus of the diagonal band of Broca and magnocellular preoptic nucleus of the basal forebrain: 66-80% of these choline acetyltransferase-positive neurons displayed neuromedinK receptor-like immunoreactivity. Neurons showing both neuromedin K receptor-like and choline acetyltransferase immunoreactivities were hardly detected in other aforementioned regions of the forebrain, brainstem and spinal cord. The present study has provided morphological evidence for direct physiological modulation or regulation of cholinergic neurons by tachykinins throughthe neuromedin K receptor in the basal forebrain of rats. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 31/03/20 alle ore 05:08:12