Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamineneurotoxicity of the nigrostriatal dopaminergic system
Autore:
Gao, X; Dluzen, DE;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 d, Dept Anat, Rootstown, OH 44272 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 385 - 394
SICI:
0306-4522(2001)103:2<385:TAENEU>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED NEUROTOXICITY; FEMALE CD-1 MICE; STRIATAL DOPAMINE; PARKINSONS-DISEASE; ESTROUS-CYCLE; SEXUAL DIFFERENCES; RAT STRIATUM; MONOAMINE-OXIDASE; GONADAL-HORMONES; BRAIN DOPAMINE;
Keywords:
corpus striatum; Parkinson's disease; neuroprotectant; dopamine; steroid hormone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Dluzen, DE NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 t, Rootstown, OH 44272 USA
Citazione:
X. Gao e D.E. Dluzen, "Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamineneurotoxicity of the nigrostriatal dopaminergic system", NEUROSCIENC, 103(2), 2001, pp. 385-394

Abstract

The effects of 17 beta -estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic systemwere examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from estrogen treated mice were significantly greater than that from non-estrogen treated mice following methamphetamine. Dopamine concentrations from estrogen + tamoxifen + methamphetamine treated mice were decreased compared to estrogen + methamphetamine treated mice and not significantly different from those of tamoxifen + methamphetamine treated miceor mice receiving methamphetamine alone. These results suggest that estrogen is functioning as a neuroprotectant of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity and that this neuroprotective effect of estrogen is abolished in the presence of tamoxifen. In Experiment 2, estrogen administration after methamphetamine treatment did not produce any significant changes in dopamine concentrations compared with methamphetamine treatment alone. The data from Experiment 2 show that estrogen cannot reverse themethamphetamine-induced neurotoxicity upon the nigrostriatal dopaminergic system. Similar results were observed for the potassium-stimulated dopamineoutputs from these treatment conditions as evaluated with in vitro superfusion, although a difference between the two measures for the estrogen + methamphetamine treated group was obtained in Experiment 1. These results have important implications for estrogen-tamoxifen interactions upon the nigrostriatal dopaminergic system and the gender differences which are observed in Parkinson's disease and animal models of nigrostriataldopaminergic neurotoxicity as well as for the proposed use of tamoxifen inpre-menopausal women at risk for breast cancer. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:32:59