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Titolo:
Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice
Autore:
Kopf, SR; Buchholzer, ML; Hilgert, M; Loffelholz, K; Klein, J;
Indirizzi:
Univ Mainz, Dept Pharmacol, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 Dept Pharmacol, D-55101 Mainz, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 365 - 371
SICI:
0306-4522(2001)103:2<365:GPCIPA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN MICRODIALYSIS; ALZHEIMERS-DISEASE; RAT HIPPOCAMPUS; IN-VIVO; MEMORY; SCOPOLAMINE; ENHANCEMENT; INJECTIONS; DIETARY; NICOTINAMIDE;
Keywords:
memory storage; precursor; novelty-induced behaviour; microdialysis; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Klein, J Univ Mainz, Dept Pharmacol, Obere Zahlbacher Str 67, D-55101 Mainz, Germany Univ Mainz Obere Zahlbacher Str 67 Mainz Germany D-55101 Germany
Citazione:
S.R. Kopf et al., "Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice", NEUROSCIENC, 103(2), 2001, pp. 365-371

Abstract

The present study tests the effects of glucose and choline, the biosynthetic precursors of acetylcholine, on passive avoidance behaviour and hippocampal acetylcholine release measured by microdialysis in awake mice. Glucose (10 and 30 mg/kg) or choline chloride (6-60 mg/kg), given by i.p. injectionimmediately after training, dose-dependently enhanced retention in an inhibitory avoidance task. Combinations of low doses of glucose (10 mg/kg) and choline chloride (20 mg/kg) which alone were submaximally effective significantly increased retention latencies in a synergistic manner, an effect which was sensitive to atropine (0.5 mg/kg). This beneficial effect vanished when higher doses of glucose or choline were combined. Basal hippocampal acetylcholine release in mice habituated to their environment was not affectedby administration of glucose and choline. However, when hippocampal acetylcholine release was stimulated either by infusion of scopolamine (0.3 muM) or by transferring the mice into a novel environment, the combination of glucose plus choline further increased acetylcholine release to a significantextent. We conclude that low doses of glucose and choline act synergistically to improve memory storage, an effect which is due to facilitation of acetylcholine release. This finding reinforces the view that central cholinergic functions are influenced under certain conditions by dietary intake of precursors. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:45:34