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Titolo:
Dahl salt-sensitive and salt-resistant rats: Examination of learning and memory performance, blood pressure, and the expression of central nicotinic acetylcholine receptors
Autore:
Terry, AV; Hernandez, CM; Buccafusco, JJ;
Indirizzi:
Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Med Coll Georgia,Augusta, GA 30912 USA Univ Georgia Augusta GA USA 30912 Med Coll Georgia,Augusta, GA 30912 USA Med Coll Georgia, Alzheimers Res Ctr, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 mers Res Ctr, Augusta, GA 30912 USA Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA Med CollGeorgia Augusta GA USA 30912 ol & Toxicol, Augusta, GA 30912 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 351 - 363
SICI:
0306-4522(2001)103:2<351:DSASRE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CHOLINERGIC RECEPTORS; NEUROPSYCHOLOGICAL PERFORMANCE; AUTORADIOGRAPHIC ANALYSIS; COGNITIVE PERFORMANCE; PARENTAL HISTORY; RISK-FACTORS; MOUSE-BRAIN; WATER-MAZE; FRAMINGHAM;
Keywords:
learning; hypertension; cholinergic; autoradiography; alpha-bungarotoxin; epibatidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Terry, AV Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Med Coll Georgia,CJ-1020, Augusta, GA 30912 USA Univ Georgia CJ-1020 Augusta GA USA 30912 Augusta, GA 30912 USA
Citazione:
A.V. Terry et al., "Dahl salt-sensitive and salt-resistant rats: Examination of learning and memory performance, blood pressure, and the expression of central nicotinic acetylcholine receptors", NEUROSCIENC, 103(2), 2001, pp. 351-363

Abstract

Substantial human and animal data suggest a correlation between hypertension and memory impairment that may appear prior to overt manifestations of cerebrovascular pathology. It is unclear, however, whether hypertension plays a causal role in these memory deficits, whether hypertension and cognitive impairment are each based in family history and not interdependent, or whether a combination of these factors is important. The purpose of this study was to assess whether deficits in memory performance and nicotinic acetylcholine receptors were present in Dahl salt-sensitive rats (as observed previously in spontaneously hypertensive rats) and whether the presence of hypertension per se (induced with an 8% Na+ diet) contributed to the deficits. Memory was assessed in a passive avoidance task, an eight-arm radial arm maze and in a water maze task, and nicotinic receptors were measured via quantitative receptor autoradiography utilizing [I-125]alpha -bungarotoxin and[H-3]epibatidine. Salt-sensitive rats exhibited impaired performance in both spatial learning tasks, but not the passive avoidance task, compared to controls (salt-resistant strain) and they exhibited reductions in nicotinicreceptors labeled by [I-125]alpha -bungarotoxin but not [H-3]epibatidine in some brain regions, including some areas important for memory (e.g. the hippocampus and amygdala). In the radial arm maze, the degree of memory impairment and in binding studies the reduced expression of nicotinic receptorseach failed to correlate with the highest blood pressures, and the salt-sensitive animals were impaired relative to controls whether or not the high Na+ diet was administered. In contrast, higher blood pressures did correlate with inferior task performance in the water maze. These findings may suggest that the genetics of the subjects were critical for performance when appetitive drives were involved, but diet (and perhaps hypertension) were keyto performance when memory did not involve appetitive drives or mechanisms. Overall, the data obtained from Dahl rats appear to support the role of family history (selective breeding in rats) as underlying the reductions in central nicotinic acetylcholine receptors, whereas both family history and hypertension may contribute to poor cognitive performance. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:25:46