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Titolo:
Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine
Autore:
Bast, T; Zhang, WN; Heidbreder, C; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Lab Behav Neurobiol, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 325 - 335
SICI:
0306-4522(2001)103:2<325:HADOPI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORIMOTOR GATING DEFICITS; PHENCYCLIDINE-INDUCED DISRUPTION; NUCLEUS-ACCUMBENS SUBREGIONS; ACOUSTIC STARTLE RESPONSE; MEDIAL PREFRONTAL CORTEX; LOCOMOTOR-ACTIVITY; CARBACHOL INFUSION; CONTEXTUAL FEAR; TEGMENTAL AREA; D-2 RECEPTORS;
Keywords:
locomotor activity; neuroleptics; NMDA; rat; schizophrenia; sensorimotor gating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Lab Behav Neurobiol, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
T. Bast et al., "Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine", NEUROSCIENC, 103(2), 2001, pp. 325-335

Abstract

This study re-examined the hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the rat ventral hippocampus and compared how both effects were affected by pretreatment with either haloperidol or clozapine. While the hyperactivity is thought to depend ondopamine receptor activation in the nucleus accumbens, the dopamine D2-class receptor blocker haloperidol failed to antagonize the disruption of prepulse inhibition in previous studies. However, an ameliorative effect of theatypical neuroleptic clozapine on disruption of prepulse inhibition was suggested by our previous experiments [Zhang et al. (1999) NeuroReport 10, 1-6]. In the present study, bilateral infusion of N-methyl-D-aspartate (0.5 mug/side) into the ventral hippocampus of Wistar rats increased open field locomotor activity and disrupted prepulse inhibition. Both effects were observed immediately after infusion but disappeared 24 h later. Injection of haloperidol (0.2 mg/kg) or clozapine (5 mg/kg), 45 min prior to N-methyl-D-aspartate infusion, totally antagonized the hyperactivity but did not affect the disruption of prepulse inhibition. We conclude that dopaminergic mechanisms are differentially involved in the hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus. Activation of accumbal dopamine receptors, which is blocked by clozapine and haloperidol to a comparable extent, seems to be crucial for the hyperactivity but not the disruption of prepulse inhibition. The present finding that both clozapine and haloperidol failed to antagonize the disruption of prepulse inhibition inducedby N-methyl-D-aspartate stimulation of the ventral hippocampus is discussed with respect to our previous contrary finding concerning the ameliorativeeffect of clozapine and with respect to the disruption of prepulse inhibition in rats being considered as a model of sensorimotor gating deficits in schizophrenia, (C) 2001 IBRO, Published by Elsevier Science Ltd. All rightsreserved.

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Documento generato il 25/01/20 alle ore 18:37:29