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Titolo:
Structural and functional abnormalities of the hippocampal formation in rats with environmentally induced reductions in prepulse inhibition of acoustic startle
Autore:
Greene, JRT; Kerkhoff, JE; Guiver, L; Totterdell, S;
Indirizzi:
Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England Univ Oxford Oxford England OX1 3QT pt Pharmacol, Oxford OX1 3QT, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 103, anno: 2001,
pagine: 315 - 323
SICI:
0306-4522(2001)103:2<315:SAFAOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROPHYSIOLOGICALLY-DEFINED CLASSES; SUBICULUM IN-VITRO; VENTRAL SUBICULUM; PYRAMIDAL NEURONS; NUCLEUS-ACCUMBENS; NADPH-DIAPHORASE; SOCIAL-ISOLATION; SCHIZOPHRENIC-PATIENTS; INTRINSIC-PROPERTIES; ANIMAL-MODEL;
Keywords:
subiculum; electrophysiology; schizophrenia; interneurons; PPI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Greene, JRT Univ Bristol, Dept Anat, MRC, Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD 1TD, Avon, England
Citazione:
J.R.T. Greene et al., "Structural and functional abnormalities of the hippocampal formation in rats with environmentally induced reductions in prepulse inhibition of acoustic startle", NEUROSCIENC, 103(2), 2001, pp. 315-323

Abstract

The effects of social isolation on prepulse inhibition of acoustic startle(PPI), electrophysiology and morphology of subicular pyramidal neurons andthe densities of interneuronal sub-types in the hippocampal formation wereexamined. Wistar rats (male weanlings) were housed socially (socials, n = 8) or individually (isolates, n = 7). When tested eight weeks later, PPI was lower in isolates. Rats then received terminal anaesthesia before slices of hippocampal formation were made in which the electrophysiological properties of a total of 108 subicular neurons were characterized. There were no differences in neuronal sub-types recorded in socials compared with isolates. Intrinsically burst-firing and regular spiking pyramidal neurons were examined in detail. There were no differences in resting membrane potential or input resistance in isolates compared with socials but action potential height was reduced and action potential threshold raised in isolates. A limited morphological examination of Neurobiotin-filled intrinsically burst-firing neurons did not reveal differences in cell-body area or in number of primary dendrites. Sections from the contralateral hemispheres of the same rats were stained with antibodies to calretinin, parvalbumin and the neuronalisoform of nitric oxide synthase (nNOS). In isolates, the density of calretinin positive neurons was increased in the dentate gyrus but unchanged in areas CA3, CA1 and subiculum. Parvalbumin and nNOS positive neuronal densities were unchanged. Hence in rats with environmentally induced reductions in PPI there are structural and functional abnormalities in the hippocampal formation. If the reduction in PPI stems from these abnormalities, and reduced PPI in rats is relevant to schizophrenia, then drugs that correct the reported electrophysiological changes might have antipsychotic effects. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:26:39