Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for neuroaxonal injury in patients with proteolipid protein gene mutations
Autore:
Bonavita, S; Schiffmann, R; Moore, DF; Frei, K; Choi, B; Patronas, N; Virta, A; Boespflug-Tanguy, O; Tedeschi, G;
Indirizzi:
NINDS, Dev & Metab Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 ab Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS, Neuroimaging Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MDUSA 20892 roimaging Branch, NIH, Bethesda, MD 20892 USA NINDS, Dept Radiol, Ctr Clin, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Radiol, Ctr Clin, NIH, Bethesda, MD 20892 USA Fac Med, INSERM, U384, Clermont Ferrand, France Fac Med Clermont FerrandFrance INSERM, U384, Clermont Ferrand, France
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 56, anno: 2001,
pagine: 785 - 788
SICI:
0028-3878(20010327)56:6<785:EFNIIP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PELIZAEUS-MERZBACHER-DISEASE; PROTON MR SPECTROSCOPY; MYELIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Schiffmann, R NINDS, Dev & Metab Neurol Branch, NIH, Bldg 10,Room 3D03,9000 Rockville Pike, Bethesda, MD 20892 USA NINDS Bldg 10,Room 3D03,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
S. Bonavita et al., "Evidence for neuroaxonal injury in patients with proteolipid protein gene mutations", NEUROLOGY, 56(6), 2001, pp. 785-788

Abstract

The authors used proton MRS to investigate neuropathologic correlates in nine patients with proteolipid protein (PLP) gene mutations who did not showcerebral atrophy on cranial MRI. When compared with 16 age-matched controlparticipants, patients with PLP mutations had significant and widespread decreased brain N-acetyl aspartate, a neuronal marker. The authors conclude that PLP mutations cause neuroaxonal injury, which in turn contributes to the neurologic deficit observed in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:47:02