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Titolo:
Cell-mediated immune response to high-passage Borrelia spirochetes in C57bl/6 mice is strictly dependent on antigen specificity
Autore:
Malovrh, T; Skoberne, M; Gruntar, I; Kotnik, V;
Indirizzi:
Med Fac Ljubljana, Inst Microbiol & Immunol, Ljubljana 1000, Slovenia Med Fac Ljubljana Ljubljana Slovenia 1000 unol, Ljubljana 1000, Slovenia
Titolo Testata:
MICROBIOLOGICAL RESEARCH
fascicolo: 4, volume: 155, anno: 2001,
pagine: 331 - 338
SICI:
0944-5013(200103)155:4<331:CIRTHB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BURGDORFERI-SENSU-STRICTO; LYME-DISEASE; T-CELLS; PROLIFERATIVE RESPONSES; PROTECTIVE ANTIBODIES; MONONUCLEAR-CELLS; MOUSE STRAINS; B-CELLS; ARTHRITIS; OSPA;
Keywords:
borrelia-immunology; lymphocyte transformation; antibodies; bacterial; infection; inbred C57bl/6 mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Malovrh, T Med Fac Ljubljana, Inst Microbiol & Immunol, Korytkova 2, Ljubljana 1000, Slovenia Med Fac Ljubljana Korytkova 2 Ljubljana Slovenia 1000 Slovenia
Citazione:
T. Malovrh et al., "Cell-mediated immune response to high-passage Borrelia spirochetes in C57bl/6 mice is strictly dependent on antigen specificity", MICROBI RES, 155(4), 2001, pp. 331-338

Abstract

Inbred C57b1/6 mice were challenged with high-passage Borrelia afzelii, Borrelia garinii and Borrelia burgdorferi sensu stricto and tested for antigen specific T-cell response in vitro. Sonicated preparations of washed spirochetes were potent cell activators, capable of stimulating polyclonal proliferation after 72h of culture while increasing the incubation time up to 120h provoked specific cell-mediated response. Isolated murine spleocytes previously sensitized to B. burgdorferi sensu late but not those from control mice could be induced for antigen-specific proliferation in vitro, as revealed by [H-3]thymidine incorporation assay, Moreover, in mice presensitized to B, burgdorferi sensu late, detectable cell-mediated response could be induced only with antigen preparations derived from a corresponding strain but not with those obtained from other Borrelia genospecies. The current study emphasises that the B, burgdorferi antigen-specific response may also be expected in different genospecies infections in men.

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Documento generato il 13/07/20 alle ore 14:51:51