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Titolo:
Longitudinal analysis of CD8(+) T-cell phenotype and IL-7, IL-15 and IL-16mRNA expression in different tissues during primary simian immunodeficiency virus infection
Autore:
Caufour, P; Le Grand, R; Cheret, A; Neildez, O; Thiebot, H; Theodoro, F; Boson, B; Vaslin, B; Venet, A; Dormont, D;
Indirizzi:
CEA, Serv Neurovirol, DSV, DRM,CRSSA,Inst Paris Sut Cytokines, F-92265 Fontenay Aux Roses, France CEA Fontenay Aux Roses France F-92265 F-92265 Fontenay Aux Roses, France Fac Med Paris Sud, Lab Virus Neurone & Immun, F-94276 Le Kremlin Bicetre, France Fac Med Paris Sud Le Kremlin Bicetre France F-94276 mlin Bicetre, France
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 3, volume: 3, anno: 2001,
pagine: 181 - 191
SICI:
1286-4579(200103)3:3<181:LAOCTP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; ACUTE SIVMAC251 INFECTION; TOXIC LYMPHOCYTES-T; HIV-INFECTION; IMMUNE-RESPONSE; SEROPOSITIVE INDIVIDUALS; EXTRAVASCULAR TISSUES; MONONUCLEAR-CELLS; VIRAL REPLICATION; CD8+ LYMPHOCYTES;
Keywords:
SIV; macaque; primary infection; cellular immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Le Grand, R CEA, Serv Neurovirol, DSV, DRM,CRSSA,Inst Paris Sut Cytokines,BP 6, F-92265 Fontenay Aux Roses, France CEA BP 6 Fontenay Aux Roses France F-92265 Aux Roses, France
Citazione:
P. Caufour et al., "Longitudinal analysis of CD8(+) T-cell phenotype and IL-7, IL-15 and IL-16mRNA expression in different tissues during primary simian immunodeficiency virus infection", MICROBES IN, 3(3), 2001, pp. 181-191

Abstract

Infection of macaques with pathogenic isolates of simian immunodeficiency virus (SIV) represents a useful model of HIV infection that offers the unique opportunity to investigate the very early modifications that affect CD8() T-lymphocyte subsets and related cytokines during lentiviral infection. Herein, three cynomolgus macaques were inoculated intravenously with a pathogenic isolate of SIVmac 251. In fresh isolated mononuclear cells from blood, lymph node and bronchoalveolar lavage, we analyzed changes in the phenotype of CD8(+) T cells and we used reverse transcription-PCR to monitor the expression of IL-7, IL-15 and IL-16 mRNA. We demonstrated that an expansionof CD8(+)CD28(-) T cells occurs from the third week of infection on in theperipheral blood and in the lung, whereas CD8(+)CD28(+) T cells expand in the lymph nodes. Concomitantly, we evidenced mRNA modulations in IL-16, IL-15 and IL-7 expression in the three compartments studied. The containment of systemic viral replication was associated with an overexpression of IL-16mRNA in the lung and in the peripheral blood. Given the immunomodulatory properties of IL-15 and IL-7 and the potential antiviral ability of IL-16, these perturbations could have important implications in early viral dissemination and HIV immunopathogenesis. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 16:46:01