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Titolo:
Quantitative trait loci affecting growth in high growth (hg) mice
Autore:
Corva, PM; Horvat, S; Medrano, JF;
Indirizzi:
Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Anim Sci, Davis, CA 95616 USA Univ Ljubljana, Biotech Fac, Zootech Dept, Domzale, Slovenia Univ Ljubljana Domzale Slovenia ch Fac, Zootech Dept, Domzale, Slovenia
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 4, volume: 12, anno: 2001,
pagine: 284 - 290
SICI:
0938-8990(200104)12:4<284:QTLAGI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID POSTWEANING GROWTH; SKELETAL-MUSCLE MASS; SIZE CONTROL; ANIMAL DEVELOPMENT; BODY-COMPOSITION; OBESITY QTLS; WEIGHT-GAIN; MAJOR GENE; MOUSE; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Medrano, JF Univ Calif Davis, Dept Anim Sci, 1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA 95616 CA 95616 USA
Citazione:
P.M. Corva et al., "Quantitative trait loci affecting growth in high growth (hg) mice", MAMM GENOME, 12(4), 2001, pp. 284-290

Abstract

A genome-wide scan was performed in order to identify Quantitative Trait Loci (QTL) associated with growth in a population segregating high growth (hg), a partially recessive mutation that enhances growth rate and body size in the mouse. A sample of 262 hg/hg mice was selected from a C57BL/6J-hg/hgX CAST/EiJ F-2 cross and typed with 79 SSLP markers distributed across thegenome. Eight significant loci were identified through interval mapping. Loci on Chromosomes (Chrs) 2 and 8 affected the growth rate of F-2 mice. Loci on Chr 2 and 11 affected growth rate and carcass lean mass (protein and ash). A locus on Chr 9 modified femur length and another one in Chr 17 affected both carcass lean mass and femur length, but none of these had significant effects on growth rate. Loci on Chrs 5 and 9 modified carcass fat content. Additive effects were positive for C57BL/6J alleles, except for the twoloci affecting carcass fatness. Typing of selected markers in 274 +/+ F-2 mice revealed significant interactions between hg and other growth QTL, which were detected as changes in gene action (additive or dominant) and in allele substitution effects. Knowledge about interactions between loci, especially when major genes are involved, will help in the identification of positional candidate genes and in the understanding of the complex genetic regulation of growth rate and body size in mammals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:15:21