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Titolo:
Quantitative trait locus analysis of abnormal circadian period in CS mice
Autore:
Suzuki, T; Ishikawa, A; Yoshimura, T; Namikawa, T; Abe, H; Honma, S; Honma, K; Ebihara, S;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Div Biomodeling, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ling, Nagoya, Aichi 4648601, Japan Nagoya Univ, Grad Sch Bioagr Sci, Div Genet & Physiol, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 siol, Nagoya, Aichi 4648601, Japan Hokkaido Univ, Sch Med, Dept Physiol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 4, volume: 12, anno: 2001,
pagine: 272 - 277
SICI:
0938-8990(200104)12:4<272:QTLAOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCOMOTOR-ACTIVITY; STRAIN DIFFERENCES; INBRED STRAINS; CLOCK GENE; MOUSE; BEHAVIOR; RHYTHMS; CLONING; QTL; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ebihara, S Nagoya Univ, Grad Sch Bioagr Sci, Div Biomodeling, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a, Aichi 4648601, Japan
Citazione:
T. Suzuki et al., "Quantitative trait locus analysis of abnormal circadian period in CS mice", MAMM GENOME, 12(4), 2001, pp. 272-277

Abstract

CS mice show a free-running period (tau) longer than 24 h and rhythm splitting in constant darkness (DD). These features in behavioral circadian rhythms are distinctive as compared with other inbred strains of mice, which exhibit robust free-running rhythms with tau shorter than 24 h. To identify the genes affecting tau, quantitative trait locus (QTL) analysis was initially conducted by using 289 F-2 mice derived from a cross between CS and C57BL/6J strain. A suggestive QTL (LOD = 3.71) with CS allele increasing tau was detected on the distal region of Chromosome (Chr) 19. Next, using 192 F-2mice from a cross between CS and MSM strain, the presence of the QTL on Chr 19 was examined, and we confirmed the QTL at the genome-wide significant level (LOD = 4.61 with 10.4% of the total variance explained). This QTL wasnamed long free-running period (Lfp). Three other suggestive QTLs (LOD = 3.24-4.28) were mapped to the midportion of Chr 12 in (CSxC57BL/6J)F-2 mice,and to the proximal and middle region of Chr 19 in (CSxMSM)F-2 mice, respectively, of which, CS alleles for two QTLs on Chr 19 have the effect of lengthening tau. None of these QTLs were mapped to the chromosomal regions of previously described QTLs for tau and known clock genes (Clock, mPer1, Bmal1, mCry1, mCry2, mTim, and Csnk1e).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:04:03