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Titolo:
The battle of two genomes: genetics of bacterial host/pathogen interactions in mice
Autore:
Lengeling, A; Pfeffer, K; Balling, R;
Indirizzi:
GSF, Res Ctr Hlth & Environm, Inst Expt Genet, D-85764 Neuherberg, GermanyGSF Neuherberg Germany D-85764 t Expt Genet, D-85764 Neuherberg, Germany GBF, Biotechnol Res Ctr, D-38124 Braunschweig, Germany GBF Braunschweig Germany D-38124 Res Ctr, D-38124 Braunschweig, Germany Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 l & Hyg, D-81675 Munich, Germany
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 4, volume: 12, anno: 2001,
pagine: 261 - 271
SICI:
0938-8990(200104)12:4<261:TBOTGG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; INTERFERON-GAMMA-RECEPTOR; MYCOBACTERIUM-TUBERCULOSIS INFECTION; STAPHYLOCOCCUS-AUREUS INFECTION; CALMETTE-GUERIN INFECTION; DISEASE RESISTANCE GENES; NADPH PHAGOCYTE OXIDASE; CELL-MEDIATED-IMMUNITY; RESOLUTION LINKAGE MAP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
150
Recensione:
Indirizzi per estratti:
Indirizzo: Lengeling, A GSF, Res Ctr Hlth & Environm, Inst Expt Genet, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany GSF Ingolstadter Landstr 1 Neuherberg Germany D-85764 ermany
Citazione:
A. Lengeling et al., "The battle of two genomes: genetics of bacterial host/pathogen interactions in mice", MAMM GENOME, 12(4), 2001, pp. 261-271

Abstract

Genetic factors strongly determine the outcome of infectious diseases caused by various pathogens. The molecular mechanisms of resistance and susceptibility in humans, however, remains largely unknown. Complex interactions of multiple genes that control the host response to a pathogen further complicate the picture. Animal models have a tremendous potential to dissect thecomplex genetic system of host-pathogen interaction into single components. This is particularly true for the mouse, which will continue to develop into an invaluable tool in the identification and cloning of host resistancegenes. Three main approaches have been taken to establish mouse models forhuman infectious diseases: 1) Production of mouse mutants by gene targeting; 2) positional cloning of host-resistance genes in mutant mice; and 3) mapping and characterization of quantitative trait loci (QTL) controlling thecomplex aspects of host-pathogen interactions. The contribution of all three methods to the understanding of infectious diseases in humans will be reviewed in this work, with a special emphasis on the studies of resistance/susceptibility mechanism in bacterial infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:16:46