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Titolo:
Body temperature dependency in baclofen-induced gastric acid secretion in rats - Relation to capsaicin-sensitive afferent neurons
Autore:
Kato, S; Araki, H; Kawauchi, S; Takeuchi, K;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 herapeut, Kyoto 6078414, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 17, volume: 68, anno: 2001,
pagine: 1951 - 1963
SICI:
0024-3205(20010316)68:17<1951:BTDIBG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL BLOOD-FLOW; GENE-RELATED PEPTIDE; SENSORY NEURONS; ANESTHETIZED RAT; NITRIC-OXIDE; TRH ANALOG; STIMULATION; STOMACH; GABA; RESPONSES;
Keywords:
baclofen; body temperature; acid secretion; gastric mucosal blood flow; gastric motility; capsaicin-sensitive afferent neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, S Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 , Kyoto 6078414, Japan
Citazione:
S. Kato et al., "Body temperature dependency in baclofen-induced gastric acid secretion in rats - Relation to capsaicin-sensitive afferent neurons", LIFE SCI, 68(17), 2001, pp. 1951-1963

Abstract

Body temperature dependency in gastric functional responses to baclofen, aGABA, agonist, such as acid secretion, mucosal blood flow (GMBF) and motoractivity, was examined in urethane-anesthetized rats under normal (37+/-1 degreesC) and hypothermic (31+/-1 degreesC) conditions. A rat stomach was mounted in an ex-vivo chamber, perfused with saline, and the acid secretion was measured using a pH-stat method, simultaneously with GMBF by a laser Doppler flowmeter. Gastric motility was measured using a miniature balloon asintraluminal pressure recordings. Intravenous administration of baclofen significantly increased acid secretion at the doses > 0.3 mg/kg under hypothermic conditions, yet it caused a significant stimulation only at doses >10mg/kg under normothermic conditions. The increases in gastric motility andGMBF were similarly induced by baclofen, irrespective of whether the animals were subjected to normothermic or hypothermic conditions. These functional responses to baclofen under hypothermic conditions were totally attenuated by either bilateral vagotomy or atropine (3 mg/kg, s.c.). Baclofen at a lower dose (1 mg/kg i.v.) significantly increased the acid secretion even under normothermic conditions when the animals were subjected to chemical deafferenation of capsaicin-sensitive neurons or pretreatment with intracisternal injection of CGRP(8-37) (30 ng/rat), These results suggest that 1) gastric effects of baclofen are dependent on body temperature in stimulating acid secretion but not GMBF or motor activity, 2) the acid stimulatory action of baclofen is enhanced under hypothermic conditions, and 3) the suppression of baclofen-induced acid response under normothermic conditions may be related to capsaicin-sensitive afferent neuronal activity, probably mediated by central release of CGRP, (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:04:04