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Titolo:
SERUM HYALURONAN LEVELS FOLLOW DISEASE-ACTIVITY IN VASCULITIS
Autore:
WEST DC; YAQOOB M;
Indirizzi:
UNIV LIVERPOOL,DEPT IMMUNOL,DUNCAN BLDG,POB 147 LIVERPOOL L69 3BX MERSEYSIDE ENGLAND ROYAL LIVERPOOL UNIV HOSP,DEPT NEPHROL LIVERPOOL MERSEYSIDE ENGLAND
Titolo Testata:
Clinical nephrology
fascicolo: 1, volume: 48, anno: 1997,
pagine: 9 - 15
SICI:
0301-0430(1997)48:1<9:SHLFDI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOPLASMIC ANTIBODY TITER; AMINO-TERMINAL PROPEPTIDE; WEGENERS GRANULOMATOSIS; CIRCULATING HYALURONATE; TRANSPLANTATION EDEMA; RHEUMATOID-ARTHRITIS; ENDOTHELIAL-CELLS; RENAL EXTRACTION; LIVER-DISEASE; ACID LEVELS;
Keywords:
SERUM HYALURONAN (HA); SYSTEMIC VASCULITIS; ACUTE RENAL FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D.C. West e M. Yaqoob, "SERUM HYALURONAN LEVELS FOLLOW DISEASE-ACTIVITY IN VASCULITIS", Clinical nephrology, 48(1), 1997, pp. 9-15

Abstract

Hyaluronan (HA) is a high molecular weight polysaccharide present in the extracellular matrix of most tissues. It is a major component of loose connective tissues such as skin, synovial fluid and the vitreous body, and during embryonic development, tissue repair, tumor growth and at inflammatory sites. Increased serum concentrations have been reported in association with tissue damage, certain inflammatory diseases,notably rheumatoid arthritis and scleroderma, liver malfunction and in some malignancies. Currently there are no serological markers available that monitor the extent of tissue damage in vasculitis. We therefore, conducted this study to investigate the significance of serum HA in patients with systemic vasculitis (SV). Ten patients with SV and acute renal failure had elevated HA levels compared to normal age and gender matched controls (n = 31) (mean +/- SD: 673.8 +/- 495.14 mu g/l and 90.26 +/- 37.18 mu g/l, respectively; p <0.001]. Eight of these patients were studied longitudinally for ten days, after pulse steroids, during which serum HA levels fell paralleling clinical improvement, despite the persistence of positive perinuclear-anti-neutrophil cytoplasmic antibody (p-ANCA) serology in three patients. In two patients, the clinical course was complicated by sepsis which was accompanied by an acute rise in serum HA. One patient suffered a relapse of vasculitis, with lung hemorrhage and a sudden rise in HA (>2,000 mu g/l), but c-ANCA serology remained normal. Serum KA was also measured in a further ten patients in clinical remission from SV and found to be within the normal range (82.44 +/- 39.06 mu g/l). One patient, with equivocal clinical relapse after transplantation, exhibited high pANCA (404 IU) but serum HA remained normal (ten readings over six months 0-163 mu g/l). Little change was seen in symptoms, or HA and ANCA serology, followingplasma exchange. These preliminary data indicate that serum HA is raised in active vasculitis and may be a useful adjunctive marker of disease activity and extent of tissue damage.

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Documento generato il 30/11/20 alle ore 09:29:26