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Titolo:
Sensitivity and specificity of third-generation hepatitis C virus antibodydetection assays: an analysis of the literature
Autore:
Colin, C; Lanoir, D; Touzet, S; Meyaud-Kraemer, L; Bailly, F; Trepo, C;
Indirizzi:
Hospices Civils Lyon, Dept Med Informat, F-69003 Lyon, France Hospices Civils Lyon Lyon France F-69003 Informat, F-69003 Lyon, France Hop Hotel Dieu, Dept Hepatogastroenterol, F-69288 Lyon, France Hop Hotel Dieu Lyon France F-69288 togastroenterol, F-69288 Lyon, France
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 87 - 95
SICI:
1352-0504(200103)8:2<87:SASOTH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT IMMUNOBLOT ASSAY; POLYMERASE CHAIN-REACTION; HCV ENZYME-IMMUNOASSAY; CONFIRMATORY ASSAYS; BLOOD-DONORS; NON-B; TESTS; INFECTION; SEROLOGY;
Keywords:
diagnostic tests; hepatitis C virus; sensitivity; specificity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Touzet, S Hospices Civils Lyon, Dept Med Informat, 162 Ave Lacassagne, F-69003 Lyon,France Hospices Civils Lyon 162 Ave Lacassagne Lyon France F-69003 nce
Citazione:
C. Colin et al., "Sensitivity and specificity of third-generation hepatitis C virus antibodydetection assays: an analysis of the literature", J VIRAL HEP, 8(2), 2001, pp. 87-95

Abstract

This study assessed the sensitivity and specificity of third-generation serological hepatitis C diagnostic tests from an analysis of the literature. The literature analysis was run using criteria from McMaster University forthe assessment of diagnostic tests. The selected studies were grouped according to the type of population at high and low risk for hepatitis C virus (HCV) infection and to the type of reference test. The homogeneity of the sensitivity and the specificity was tested in each group using a Fisher's exact test. Of 132 studies, 10 were selected. When the estimates were homogeneous, summary point estimates and confidence intervals were computed; when the estimates were heterogeneous, subgroup analysis was performed. The sensitivity of third-generation enzyme-linked immunosorbent assay (ELISA3) was estimated at 98.9% (95% CI: 94-100%) in patients with chronic liver disease and at 97.2% (95% CI: 92-99%) in panels of sera. ELISA3 specificity was found at 100% in patients with chronic liver disease. The sensitivity of the third generation recombinant immunoblot assay (RIBA3) was assessedat 78.8% (95% CI: 65-89%) in haemodialysed patients. This analysis provides evidence for the good sensitivity and specificity of ELISA3 assays particularly in high risk patient groups and confirms theiruse for screening in these populations. Further studies are needed to assess properly RIBA3 in general population and in risk patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:41:09