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Titolo:
Effects of indole-3-carbinol on immune responses, aberrant crypt foci, andcolonic crypt cell proliferation in rats
Autore:
Exon, JH; South, EH; Magnuson, BA; Hendrix, K;
Indirizzi:
Univ Idaho, Dept Food Sci & Technol, Moscow, ID 83844 USA Univ Idaho Moscow ID USA 83844 t Food Sci & Technol, Moscow, ID 83844 USA Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA Univ Maryland College Pk MD USA 20742 Food Sci, College Pk, MD 20742 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 7, volume: 62, anno: 2001,
pagine: 561 - 573
SICI:
1528-7394(20010406)62:7<561:EOIOIR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY INDOLE-3-CARBINOL; RISK ASSESSMENT; CARCINOGENESIS; CANCER; LIVER; CHEMOPREVENTION; ENHANCEMENT; METABOLISM; AGENTS; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Exon, JH Univ Idaho, Dept Food Sci & Technol, Moscow, ID 83844 USA Univ Idaho Moscow ID USA 83844 i & Technol, Moscow, ID 83844 USA
Citazione:
J.H. Exon et al., "Effects of indole-3-carbinol on immune responses, aberrant crypt foci, andcolonic crypt cell proliferation in rats", J TOX E H A, 62(7), 2001, pp. 561-573

Abstract

Male Sprague-Dawley rats were treated orally with indole-3-carbinol (13C) for 7 wk at levels of 150, 100, and 50 mg/kg body weight. The rats were injected with 10 mg/kg body weight of the colon carcinogen, azoxymethane (AOM)on d 2 and 9 of 13C treat ment. At termination of the study, all rats wereassessed for immune function (humoral immunity, specific cell-mediated immunity, and nonspecific cell-mediated immunity). Colonic tissue was collected and examined for the presence of aberrant crypt loci (ACF) and proliferation of crypt cells. Antibody responses to antigen challenge were significantly suppressed in the animals exposed to the high dose of 13C. Delayed-typehypersensitivity responses, natural killer cell activity, the number and multiplicity of ACF, and cell proliferation parameters were not significantly different from those of the controls. Therefore, there was no clear protective or enhancing effect of 13C on ACF numbers or colonic cell proliferation indices. There was no strong correlation between changes in immune responses and the preneoplastic biomarkers of colon cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:58:48