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Titolo:
Influence of propylthiouracil treatment on oxidative stress and nitric oxide in Basedow disease patients
Autore:
Seven, R; Gelisgen, R; Seven, A; Erbil, Y; Bozbora, A; Burcak, G;
Indirizzi:
Istanbul Univ, Istanbul Fac Med, Dept Gen Surg, Istanbul, Turkey Istanbul Univ Istanbul Turkey Fac Med, Dept Gen Surg, Istanbul, Turkey Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey IstanbulUniv Istanbul Turkey a Med Fac, Dept Biochem, Istanbul, Turkey
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 7, volume: 62, anno: 2001,
pagine: 495 - 503
SICI:
1528-7394(20010406)62:7<495:IOPTOO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICAL SCAVENGERS; LIPID-PEROXIDATION; THYROID-HORMONE; EXPRESSION; SYNTHASE; HYPERTHYROIDISM; RATS; ANTIOXIDANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Seven, R Akatlar Maya Sitesi C-11, Akatlar Istanbul, Turkey Akatlar Maya Sitesi C-11 Akatlar Istanbul Turkey anbul, Turkey
Citazione:
R. Seven et al., "Influence of propylthiouracil treatment on oxidative stress and nitric oxide in Basedow disease patients", J TOX E H A, 62(7), 2001, pp. 495-503

Abstract

Oxidative stress parameters and nitric oxide (NO) values were determined in 27 newly diagnosed Basedow patients before and afer 1 mo of propylthiouracil (PTU) therapy and in 15 healthy controls. Basedow patients exhibited increased triiodothyronine (T-3) and thyroxine (T-4) and decreased thyroid-stimulating hormone (TSH) values compared to controls. Significantly higher thiobarbituric acid-reactive substances (TBARS), NO and glutathione (GSH) levels, and CuZn superoxide dismutase (CuZn SOD) activity were found in Basedow patients in comparison to controls, regardless of sex. Treatment with PTU (3 x 100 mg/d for 30 d) was effective in decreasing T-3 and T-4 and increasing TSH levels. Significantly decreased NO and TBARS and increased GSH and CuZn SOD levels were observed in PTU-treated Basedow patients compared topre-PTU administration. PTU-treated patients compared to controls still exhibited significantly higher T-3 and lower TSH values and higher NO, TBARS,GSH, and CuZn SOD levels. The induced antioxidant defense and decrease in NO values in response to PTU therapy emphasizes the role of PTU as an antithyroid drug, where the ability to diminish hyperthyroidism results in decreased catabolism and lower oxidant generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:02:43