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Titolo:
Autonomic dysfunction in experimental autoimmune neuritis: Heart rate
Autore:
Wang, N; Chapman, J; Rabinowitz, R; Viskin, S; Kafri, M; Korczyn, AD;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Neurol, IL-69978 Tel Aviv, Israel TelAviv Univ Tel Aviv Israel IL-69978 Neurol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Cardiol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ardiol, IL-69978 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 184, anno: 2001,
pagine: 183 - 188
SICI:
0022-510X(20010301)184:2<183:ADIEAN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUILLAIN-BARRE-SYNDROME; EXPERIMENTAL ALLERGIC NEURITIS; LEWIS RAT; DEMYELINATION; MYELIN;
Keywords:
Guillain-Barre syndrome; experimental autoimmune neuritis; cardiac dysfunction; ECG; heart rate; autonomic nervous system; nerve conduction velocity; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Korczyn, AD Tel Aviv Univ, Sackler Fac Med, Sieratzki Chair Neurol, IL-69978 Tel Aviv,Israel Tel Aviv Univ Tel Aviv Israel IL-69978 69978 Tel Aviv,Israel
Citazione:
N. Wang et al., "Autonomic dysfunction in experimental autoimmune neuritis: Heart rate", J NEUR SCI, 184(2), 2001, pp. 183-188

Abstract

Autonomic nervous system (ANS) dysfunction occurs in more than half of Guillain-Barre syndrome (GBS) patients and is an important cause of death in the disease. In this study we examined heart rate (HR) changes in an animal model of GBS, experimental autoimmune neuritis (EAN), induced by immunization with myelin extracted from bovine spinal roots. The animals developed progressive motor weakness accompanied by significant weight loss and hypothermia. HR was measured in 33 EAN rats at rest (rHR) and followings stressfulstimulation (sHR). Average pre-immunization rHR was 341 +/- 28 beats per minute (b.p.m.) and sHR was 486 +/- 21 bpm. Although the mean rHR in rats with EAN was not significantly different compared to that at baseline, there was a significant increase of variation of rHR with six rats demonstrating bradycardia (<280 b.p.m.) and 10 tachycardia (>400 b.p.m. ) (P<0.01, F-test). sHR in EAN rats was significantly lower (P<0.01), suggesting sympathetic system impairment. These findings may serve as a basis for testing treatments of ANS dysfunction in EAN. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 11/07/20 alle ore 04:05:52