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Titolo:
CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese
Autore:
Rasmussen, HB; Kelly, MA; Francis, DA; Clausen, J;
Indirizzi:
Roskilde Univ Ctr, Dept Life Sci, DK-4000 Roskilde, Denmark Roskilde Univ Ctr Roskilde Denmark DK-4000 ci, DK-4000 Roskilde, Denmark Univ Birmingham, Div Med Sci, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Queen Elizabeth Neurosci Ctr, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Neurosci Ctr Birmingham W Midlands England B15 2TH ngland
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 184, anno: 2001,
pagine: 143 - 147
SICI:
0022-510X(20010301)184:2<143:CIMSLO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HASHIMOTOS-THYROIDITIS; GRAVES-DISEASE; POLYMORPHISM; SUSCEPTIBILITY; PROMOTER;
Keywords:
multiple sclerosis; genetic susceptibility; CTLA4; HLA-DR2; gene interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, HB Roskilde Univ Ctr, Dept Life Sci, POB 260, DK-4000 Roskilde,Denmark Roskilde Univ Ctr POB 260 Roskilde Denmark DK-4000 Denmark
Citazione:
H.B. Rasmussen et al., "CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese", J NEUR SCI, 184(2), 2001, pp. 143-147

Abstract

In the present study we searched for an association between multiple sclerosis (MS) and the gene encoding the cytotoxic T lymphocyte antigen 4 (CTLA4). Our experimental approach involved amplification of DNA fragments of thepromoter and exon 1 of this gene containing single nucleotide polymorphisms followed by treatment of the amplified fragments with restriction enzymesfor allele determination. Included in the study were 84 MS patients and 125 healthy control subjects from a population of white Caucasians. We also examined 42 MS patients and 86 healthy control subjects of Shanghai Chinese origin. Significant differences in the distribution of genotypes or haplotypes of the CTLA4 gene were not observed between MS patients and control subjects in either of the two populations (P>0.05). Moreover, we were not ableto confirm a previous finding of an association between relapsing-remitting MS and the heterozygous genotype A/G of CTLA4 exon 1. There was no evidence to suggest that interaction between HLA-DR2 and CTLA4 is involved in thedevelopment of MS among European Caucasians (P>0.05). Opposed to this, analysis of the Shanghai Chinese suggested presence of such interaction (P=0.02). Our results do not support the assumption that CTLA4 influences susceptibility to MS in European Caucasians. On the other hand, they raise the possibility that the development of MS in other ethnic groups involves interaction between CTLA4 and DR2. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/11/20 alle ore 08:18:00