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Titolo:
Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats
Autore:
Budygin, EA; Phillips, PEM; Robinson, DL; Kennedy, AP; Gainetdinov, RR; Wightman, RM;
Indirizzi:
Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Chem, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA Duke Univ, Dept Cell Biol, Durham, NC USA Duke Univ Durham NC USADuke Univ, Dept Cell Biol, Durham, NC USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 297, anno: 2001,
pagine: 27 - 34
SICI:
0022-3565(200104)297:1<27:EOAEOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; NUCLEUS-ACCUMBENS; IN-VIVO; EXTRACELLULAR DOPAMINE; CYCLIC VOLTAMMETRY; BRAIN ETHANOL; RELEASE; NEURONS; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Wightman, RM Univ N Carolina, Dept Chem, Venable Hall,CB 3290, Chapel Hill, NC 27599 USA Univ N Carolina Venable Hall,CB 3290 Chapel Hill NC USA 27599
Citazione:
E.A. Budygin et al., "Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats", J PHARM EXP, 297(1), 2001, pp. 27-34

Abstract

The effect of ethanol on evoked dopamine release in the caudate putamen has been measured in behaving animals with in vivo electrochemistry. Dopaminewas measured with fast-scan cyclic voltammetry in adult male rats to resolve the competing processes of dopamine uptake and release. Ethanol dose dependently decreased dopamine efflux compared with saline-treated animals: to89% of controls with 0.5 g/kg, 70% with 1 g/kg, 34% with 2.5 g/kg, and 18%with 5 g/kg. This decrease was not due to a change in uptake, as measured by the rate of dopamine disappearance after stimulation, and therefore can be attributed to decreased dopamine release. Additionally, it was not mediated by a decrease in biosynthesis, as measured by L-DOPA accumulation afterNSD 1015 administration. The selective dopamine uptake inhibitor GBR 12909compensated for the effects of high doses of ethanol on dopamine release. Moreover, GBR 12909 induced faster restoration of the righting reflex in rats sedated with 2.5 g/kg, but not 5 g/kg, ethanol. In brain slices containing the caudate putamen, ethanol suppressed dopamine release only at the highest dose tested (200 mM). The difference in responses between the slice and the intact animal indicates that ethanol exerts its effects in the cell body regions of dopamine neurons as well as in terminals. These neurochemical results, combined with published accounts of microdialysis measures of extracellular dopamine and electrophysiological recordings of dopamine neurons, demonstrate that ethanol has a profound effect on dopamine neurons whosenet result is a suppression of dopamine neurotransmission at high doses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:01:57