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Titolo:
Self-protective mechanism awakened by glutamate in retinal ganglion cells
Autore:
Yoles, E; Friedmann, I; Barouch, R; Shani, Y; Schwartz, M;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 3, volume: 18, anno: 2001,
pagine: 339 - 349
SICI:
0897-7151(200103)18:3<339:SMABGI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
P75 NEUROTROPHIN RECEPTOR; OPTIC-NERVE; OXIDATIVE STRESS; NMDA RECEPTORS; DEATH; BCL-2; BRAIN; NEUROTOXICITY; ACTIVATION; GLAUCOMA;
Keywords:
glaucoma; glutamate; neuroprotection; optic neuropathy; retinal degeneration; visual evoked potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, M Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 00 Rehovot, Israel
Citazione:
E. Yoles et al., "Self-protective mechanism awakened by glutamate in retinal ganglion cells", J NEUROTRAU, 18(3), 2001, pp. 339-349

Abstract

The progression of degeneration in chronic optic neuropathies or in animalmodels of optic nerve injury is thought to be caused, at least in part, byan increase in glutamate to abnormally high concentrations. We show here that glutamate, when injected in subtoxic amounts into the vitreal body of the rat eye, transduces a self-protecting signal that renders the retinal ganglion cells resistant to further toxicity, whether glutamate-derived or not. This neuroprotective effect is attained within 24 h and lasts at least 4days. Western blot analysis of rat retinas revealed increased amounts of bcI-2 four days after injection of glutamate in either subtoxic or toxic (120 nmol) amounts, but not after saline injection. The effects of intravitreal glutamate or saline injection on the secretion of neurotrophins by retinal ganglion cells was evaluated in rat aqueous humor 6 h, 1 day, and 4 days after injection. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 showed similar kinetic patterns in all of the eyes; that is, they increased to a peak 1 day after the injection and returned to normal by day 4. However, increased amounts the neurotrophin receptor TrkA within the retinal ganglion cell layer and nerve fiber layer were detected 1 dayafter injection of glutamate in either toxic or subtoxic amounts, but not after saline injection. This finding points to the possible involvement of neurotrophin receptors in regulation of the cellular responses to glutamatechallenge. Identification of the intracellular signals that trigger the glutamate-induced self-protective mechanism would shed light on the genetic balance needed for survival, and guide the development of drugs for the up-regulation of desired genes and their products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:13:28