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Titolo:
Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury
Autore:
Stibick, DL; Feeney, DM;
Indirizzi:
Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA Univ New MexicoAlbuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 3, volume: 18, anno: 2001,
pagine: 303 - 312
SICI:
0897-7151(200103)18:3<303:EVTTRO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORIMOTOR CORTEX CONTUSION; CORTICAL INJURY; RECOVERY; RAT; AMPHETAMINE; NEURONS; MOTOR; NOREPINEPHRINE; ORGANIZATION; RECEPTORS;
Keywords:
alpha(1) noradrenergic receptors; brain injury; noradrenaline; prazosin; reinstatement; trauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Feeney, DM Univ New Mexico, Dept Psychol, Logan Hall, Albuquerque, NM 87131 USA Univ New Mexico Logan Hall Albuquerque NM USA 87131 M 87131 USA
Citazione:
D.L. Stibick e D.M. Feeney, "Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury", J NEUROTRAU, 18(3), 2001, pp. 303-312

Abstract

A single dose of an alpha (1)-noradrenergic antagonist transiently reinstates hemiplegia after recovery from brain injury, which suggests that noradrenaline (NA) is required to maintain recovery. No systematic studies have determined the postinjury duration of this vulnerability. This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha (1)-NA antagonist, or propranolol (PROP), a beta -NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI), PRAZ transiently reinstated hemiplegia as measured by beam walk (BW) score in a dose-dependent manner, with the same degree of symptom reinstatement at 1, 3, 6, and 12 months post-TBI, Between-animal variability in reinstatement of hemiplegia by PRAZ was predicted by severity of deficits in BW ability 24 h after TBI, In contrast, PRAZ didnot reinstate tactile placing deficits at 1 month post-TBI suggesting a different mechanism of maintaining recovery for each task. Reinstatement of symptoms are not due to sedation. Only TBI rats receiving PRAZ, not high, sedating doses of PROP or saline (SAL), showed return of hemiplegia, These data indicate that vulnerability to transient reinstatement of hemiplegia on some tasks endures long after functional recovery from TBI.

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Documento generato il 10/04/20 alle ore 00:22:27