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Titolo:
Altered cellular metabolism following traumatic brain injury: A magnetic resonance spectroscopy study
Autore:
Garnett, MR; Corkill, RG; Blamire, AM; Rajagopalan, B; Manners, DN; Young, JD; Styles, P; Cadoux-Hudson, TAD;
Indirizzi:
John Radcliffe Hosp, Dept Biochem, MRC, Biochem & Clin Magnet Resonance Unit, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Unit, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Neurosurg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU surg, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Neurol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU urol, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Anaesthet, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU thet, Oxford OX3 9DU, England
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 3, volume: 18, anno: 2001,
pagine: 231 - 240
SICI:
0897-7151(200103)18:3<231:ACMFTB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFUSE AXONAL INJURY; CLOSED-HEAD INJURY; FREE MAGNESIUM CONCENTRATION; FOCAL CEREBRAL-ISCHEMIA; P-31 NMR-SPECTROSCOPY; MR SPECTROSCOPY; PHOSPHATE-METABOLISM; INTRACRANIAL TUMORS; INITIAL EXPERIENCE; ENERGY-METABOLISM;
Keywords:
diffuse axonal injury; magnesium; magnetic resonance spectroscopy; metabolism; phosphorus; proton; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Garnett, MR John Radcliffe Hosp, Dept Biochem, MRC, Biochem & Clin Magnet Resonance Unit, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU OX3 9DU, England
Citazione:
M.R. Garnett et al., "Altered cellular metabolism following traumatic brain injury: A magnetic resonance spectroscopy study", J NEUROTRAU, 18(3), 2001, pp. 231-240

Abstract

Experimental studies have reported early reductions in pH, phosphocreatine, and free intracellular magnesium following traumatic brain injury using phosphorus magnetic resonance spectroscopy. Paradoxically, in clinical studies there is some evidence for an increase in the pH in the subacute stage following traumatic brain injury. We therefore performed phosphorus magneticresonance spectroscopy on seven patients in the subacute stage (mean 9 days postinjury) following traumatic brain injury to assess cellular metabolism. In areas of normal-appearing white matter, the pH was significantly alkaline (patients 7.09 +/- 0.04 [mean +/- SD], controls 7.01 +/- 0.04, p = 0.008), the phosphocreatine to inorganic phosphate ratio (PCr/Pi) was significantly increased (patients 4.03 +/- 1.18, controls 2.64 +/- 0.71, p = 0.03),the inorganic phosphate to adenosine triphosphate ratio (Pi/ATP) was significantly reduced (patients 0.37 +/- 0.10, controls 0.56 +/- 0.19, p = 0.04), and the PCr/ATP ratio was nonsignificantly increased (patients 1.53 +/- 0.29, controls 1.34 +/- 0.19, p = 0.14) in patients compared to controls. Furthermore, the calculated free intracellular magnesium was significantly increased in the patients compared to the controls (patients 0.33 +/- 0.09 mM, controls 0.22 +/- 0.09 mM, p = 0.03). Proton spectra, acquired from similar regions showed a significant reduction in N-acetylaspartate (patients 9.64 +/- 2.49 units, controls 12.84 +/- 2.35 units, p = 0.03) and a significant increase in choline compounds (patients 7.96 +/- 1.02, controls 6.67 +/-1.01 units, p = 0.03). No lactate was visible in any patient or control spectrum. The alterations in metabolism observed in these patients could not be explained by ongoing ischemia but might be secondary to a loss of normalcellular homeostasis or a relative alteration in the cellular population, in particular an increase in the glial cell density, in these regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:28:16