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Titolo:
Temporal profiles of the levels of endogenous antioxidants after four-vessel occlusion in rats
Autore:
Namba, K; Takeda, Y; Sunami, K; Hirakawa, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Anesthesiol & Resuscitol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 & Resuscitol, Okayama 7008558, Japan
Titolo Testata:
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 131 - 137
SICI:
0898-4921(200104)13:2<131:TPOTLO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; GLOBAL CEREBRAL-ISCHEMIA; SUPEROXIDE-DISMUTASE; GLUTATHIONE-PEROXIDASE; REGIONAL DISTRIBUTION; HEMISPHERIC ISCHEMIA; BRAIN; CATALASE; REPERFUSION; DEPLETION;
Keywords:
free radical; oxygen stress; superoxide dismutase; glutathione; glutathione peroxidase; catalase; four-vessel occlusion; brain ischemia; antioxidants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Okayama Univ, Sch Med, Dept Anesthesiol & Resuscitol, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 558, Japan
Citazione:
K. Namba et al., "Temporal profiles of the levels of endogenous antioxidants after four-vessel occlusion in rats", J NEUROS AN, 13(2), 2001, pp. 131-137

Abstract

Although it is known that development of lipid peroxidation after ischemiaoccurs predominantly in vulnerable regions, temporal profiles of antioxidants after ischemia have not been regionally elucidated. After reperfusion periods of 0, 3, 24, and 72 hours following 20 minutes of four-vessel occlusion (n = 6 in each group), the concentration of total glutathione (GSH) andthe activities of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) were assayed in the hippocampus, parietal cortex, striatum, thalamus, and brain stem. The levels of all antioxidants were unchanged in all regions without reperfusion; however, the concentration of total GSH significantly decreased in the hippocampus at 3 hours after the onset of reperfusion, and showed a maximum decrease in the hippocampus (68% of the sham-control level), parietal cortex (78% of the sham-control level), and striatum (76% of the sham-control level) after 24 hours of reperfusion. After 72 hours of reperfusion, these regions and the thalamus showed restoration and an increase in the totalGSH concentration, respectively. The activities of SOD, GSH-Px, and catalase were stable during the: reperfusion period, but the hippocampus showed significant increases in these enzyme activities and the parietal cortex andstriatum showed significant increases in SOD activities at 72 hours after the onset of reperfusion. These results indicate that endogenous antioxidants take 72 hours for restoration in vulnerable regions after 20 minutes of four-vessel occlusion in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:44:13