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Titolo:
Postlearning consolidation of birdsong: Stabilizing effects of age and anterior forebrain lesions
Autore:
Brainard, MS; Doupe, AJ;
Indirizzi:
Univ Calif San Francisco, Keck Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 21, anno: 2001,
pagine: 2501 - 2517
SICI:
0270-6474(20010401)21:7<2501:PCOBSE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT ZEBRA FINCHES; BASAL GANGLIA; POEPHILA-GUTTATA; SONG DEVELOPMENT; FUNDAMENTAL-FREQUENCY; ASSOCIATIONAL MODEL; PARKINSONS-DISEASE; AUDITORY-FEEDBACK; NEURAL ACTIVITY; MOTOR PATHWAY;
Keywords:
basal ganglia; song learning; motor learning; memory consolidation; timing; language; speech; auditory feedback; hearing loss; deafness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Brainard, MS Univ Calif San Francisco, Keck Ctr Integrat Neurosci, Dept Physiol, Box 0444,513 Parnassus Ave, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0444,513 Parnassus Ave San Francisco CA USA 94143
Citazione:
M.S. Brainard e A.J. Doupe, "Postlearning consolidation of birdsong: Stabilizing effects of age and anterior forebrain lesions", J NEUROSC, 21(7), 2001, pp. 2501-2517

Abstract

Birdsong is a learned. sequenced motor skill. For the zebra finch, learnedsong normally remains unchanging beyond early adulthood. However, stable adult song will gradually deteriorate after deafening (Nordeen and Nordeen, 1992), indicating an ongoing influence of auditory feedback on learned song. This plasticity of adult song in response to deafening gradually declineswith age (Lombardino and Nottebohm, 2000), suggesting that, after song learning, there continue to be changes in the brain that progressively stabilize the song motor program. A qualitatively similar stabilization of learnedsong can be precipitated artificially by lesions of a basal ganglia circuit in the songbird anterior forebrain (Brainard and Doupe, 2000), raising the question of whether and how these two forms of song stabilization are related. We investigated this issue by characterizing the deterioration of song that occurs after deafening in young adult birds and the degree to which that deterioration is reduced by age or by lesions of the anterior forebrain that were directed at the lateral portion of the magnocellular nucleus ofthe anterior neostriatum (LMAN). In most respects, LMAN lesions stabilizedsong to a significantly greater extent than did aging; whereas old-deafened birds eventually exhibited significant deterioration of song, lesioned-deafened birds generally did not differ from controls. The one exception was for song tempo, which was significantly stabilized by age, but not by LMAN lesions. The results indicate that LMAN lesions do not simply mimic a normal aging process, and likewise suggest that the anterior forebrain pathway continues to play a role even in the residual song plasticity that is observed after the age-dependent stabilization of song.

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Documento generato il 23/01/20 alle ore 13:14:16