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Titolo:
Olfactory fingerprints for major histocompatibility complex-determined body odors
Autore:
Schaefer, ML; Young, DA; Restrepo, D;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Cellular & Struct Biol, Denver, CO 80262USA Univ Colorado Denver CO USA 80262 ular & Struct Biol, Denver, CO 80262USA Univ Colorado, Hlth Sci Ctr, Neurosci Program, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Neurosci Program, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Rocky Mt Taste & Smell Ctr, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Taste & Smell Ctr, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, Biometr Sect, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 etr, Biometr Sect, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 21, anno: 2001,
pagine: 2481 - 2487
SICI:
0270-6474(20010401)21:7<2481:OFFMHC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR LAYER; MATING PREFERENCES; YOUNG-RATS; BULB; MICE; MOUSE; RECOGNITION; ODORTYPES; PATTERNS; FOS;
Keywords:
major histocompatibility complex; congenic mice; olfactory; urine; coding; recognition; c-fos; complex odors; mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Restrepo, D Univ Colorado, Hlth Sci Ctr, Dept Cellular & Struct Biol, 4200E 9th Ave,Room 4505 SOM, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave,Room 4505 SOM Denver CO USA 80262
Citazione:
M.L. Schaefer et al., "Olfactory fingerprints for major histocompatibility complex-determined body odors", J NEUROSC, 21(7), 2001, pp. 2481-2487

Abstract

Recognition of individual body odors is analogous to human face recognition in that it provides information about identity. Individual body odors determined by differences at the major histocompatibility complex (MHC or H-2)have been shown to influence mate choice, pregnancy block, and maternal behavior in mice. Unfortunately, the mechanism and extent of the main olfactory bulb (MOB) and accessory olfactory bulb (AOB) involvement in the discrimination of animals according to H-2-type has remained ambiguous. Here we study the neuronal activation patterns evoked in the MOB in different individuals on exposure to these complex, biologically meaningful sensory stimuli. We demonstrate that body odors from H-2 disparate mice evoke overlapping but distinct maps of neuronal activation in the MOB. The spatial patterns ofodor-evoked activity are sufficient to be used like fingerprints to predict H-2 identity using a novel computer algorithm. These results provide functional evidence for discrimination of H-2-determined body odors in the MOB,but do not preclude a role for the AOB. These data further our understanding of the neural strategies used to decode socially relevant odors.

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Documento generato il 04/04/20 alle ore 09:02:08