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Titolo:
Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat
Autore:
Gozal, D; Daniel, JM; Dohanich, GP;
Indirizzi:
Univ Louisville, Sch Med, Kosair Childrens Hosp, Res Inst,Dept Pediat, Louisville, KY 40202 USA Univ Louisville Louisville KY USA 40202 Pediat, Louisville, KY 40202 USA Univ Louisville, Sch Med, Kosair Childrens Hosp, Res Inst,Dept Pharmacol, Louisville, KY 40202 USA Univ Louisville Louisville KY USA 40202 armacol, Louisville, KY 40202 USA Univ Louisville, Sch Med, Kosair Childrens Hosp, Res Inst,Dept Toxicol, Louisville, KY 40202 USA Univ Louisville Louisville KY USA 40202 Toxicol, Louisville, KY 40202 USA Tulane Univ, Dept Psychol, New Orleans, LA 70118 USA Tulane Univ New Orleans LA USA 70118 t Psychol, New Orleans, LA 70118 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 21, anno: 2001,
pagine: 2442 - 2450
SICI:
0270-6474(20010401)21:7<2442:BAACOC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-INTERMITTENT HYPOXIA; D-ASPARTATE RECEPTOR; NEURONAL CELL-DEATH; APNEA SYNDROME OSAS; C-FOS; NEUROPSYCHOLOGICAL DEFICITS; NERVOUS-SYSTEM; DEPRIVATION; EXPRESSION; APOPTOSIS;
Keywords:
sleep; apoptosis; intermittent hypoxia; immediate early genes; glutamate receptors; obstructive sleep apnea; cognitive impairment; memory; water maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Gozal, D Univ Louisville, Sch Med, Kosair Childrens Hosp, Res Inst,Dept Pediat, 570S Preston St,Suite 321, Louisville, KY 40202 USA Univ Louisville 570 S Preston St,Suite 321 Louisville KY USA 40202
Citazione:
D. Gozal et al., "Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat", J NEUROSC, 21(7), 2001, pp. 2442-2450

Abstract

The role played by chronic episodic hypoxia (EHYP) in the neurocognitive morbidity of obstructive sleep apnea (OSA) is unknown. Sleep recordings, Morris water maze experiments, and immunohistochemistry for NMDA NR1 glutamatereceptor, c-fos protein, and apoptosis [nuclear immunoreactivity for single-stranded DNA and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling assay] were conducted in EHYP-exposed Sprague Dawley male rats. Exposures consisted of up to 14 d in an environmental chamber in which O-2 concentrations were cycled between 10 and 21% every 90 sec or 30 min during 12 hr of daylight. For the remaining 12 hr, EHYP rats breathed room air, while controls spent 14 d in room air. Although EHYP induced significant disruption of sleep architecture during the initial day of exposure, sleep patterns normalized thereafter. Marked increases in apoptosis occurred in the CA1 hippocampal region (sevenfold) and cortex (Cx; eightfold) after 1-2 d of EHYP but not in CA3 and were followed by decreases toward normoxic levels by 14 d. Double labeling for NMDA NR1 and c-fos revealed marked architectural disorganization in CA1 and Cx with increases in c-fos over time. Rats exposed to EHYP displayed significantly longer escape latencies and swim path lengths to escape a hidden platform during 12 training trials given over 2 d. Differences in the performances of EHYP and control rats, although reduced, persisted after 14 d of recovery. We conclude that EHYP is associated with marked cellular changes over time within neural regions associated with cognitive functions. Furthermore, EHYP impaired performance during acquisition of a cognitive spatial task without affecting sensorimotor function. Such changes may underlie components of the learning and memory impairments found in OSA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:55:09