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Titolo:
The differential regulation of CART gene expression in a pituitary cell line and primary cell cultures of ovine pars tuberalis cells
Autore:
Barrett, P; Morris, MA; Moar, KM; Mercer, JG; Davidson, JA; Findlay, PA; Adam, CL; Morgan, PJ;
Indirizzi:
Rowett Res Inst, Aberdeen Ctr Energy Regulat & Obes, Mol Neuroendocrinol Grp, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 347 - 352
SICI:
0953-8194(200104)13:4<347:TDROCG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; ADENYLATE-CYCLASE; PROOPIOMELANOCORTIN GENE; MESSENGER-RNA; TRANSCRIPTION; HYPOTHALAMUS; AMPHETAMINE; MELATONIN; MECHANISM; COCAINE;
Keywords:
hypothalamus; neuropeptide; obesity; appetite; pituitary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Barrett, P Rowett Res Inst, Aberdeen Ctr Energy Regulat & Obes, Mol Neuroendocrinol Grp, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB AB21 9SB, Scotland
Citazione:
P. Barrett et al., "The differential regulation of CART gene expression in a pituitary cell line and primary cell cultures of ovine pars tuberalis cells", J NEUROENDO, 13(4), 2001, pp. 347-352

Abstract

The cocaine-amphetamine regulated transcript (CART) encodes for a protein which has an important role in the regulation of appetite and body weight. To date, no details of the molecular events and signal transduction pathways which regulate this gene are available. We report the identification of CART gene expression in the GH3 pituitary cell line. We have used activatorsof the cAMP or protein kinase C (PKC) signal transduction pathways to showthat, in GH3 cells, CART is transcriptionally up-regulated by activators of the cAMP signal transduction pathway. We also identify CART gene expression in ovine pars tuberalis (PT) tissue and primary cell cultures. In PT cells in contrast to GH3 cells, CART gene expression is upregulated by activators of the PKC signal transduction pathway. Cultured cells have provided a valuable resource for the detailed analysis of specific regulatory mechanisms underlying transcriptional or translational regulation of genes, signal transduction events and many other cellular processes. GH3 and PT cells maytherefore provide a resource for the further detailed molecular analysis of the events regulating CART gene expression and processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:55:39