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Titolo:
Brain monoamine receptors in a chronic unpredictable stress model in rats
Autore:
Ossowska, G; Nowak, G; Kata, R; Klenk-Majewska, B; Danilczuk, Z; Zebrowska-Lupina, F;
Indirizzi:
Med Univ Sch, Dept Clin Pharmacol, Lublin, Poland Med Univ Sch Lublin Poland niv Sch, Dept Clin Pharmacol, Lublin, Poland Polish Acad Sci, Inst Pharmacol, PL-00901 Warsaw, Poland Polish Acad Sci Warsaw Poland PL-00901 harmacol, PL-00901 Warsaw, Poland Jagiellonian Univ, Collegium Medicum, Lab Radiol Res, Krakow, Poland Jagiellonian Univ Krakow Poland Medicum, Lab Radiol Res, Krakow, Poland
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 3, volume: 108, anno: 2001,
pagine: 311 - 319
SICI:
0300-9564(2001)108:3<311:BMRIAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
REALISTIC ANIMAL-MODEL; DEPRESSED-PATIENTS; BINDING-SITES; MILD STRESS; MESOLIMBIC DOPAMINE; INDUCED ANHEDONIA; SUICIDE VICTIMS; ANTIDEPRESSANT DRUGS; INCREASED SEROTONIN2; MEDIATED BEHAVIOR;
Keywords:
brain; monoamine receptors; chronic stress; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Nowak, G Med Univ Sch, Dept Clin Pharmacol, Lublin, Poland Med Univ Sch Lublin Poland Dept Clin Pharmacol, Lublin, Poland
Citazione:
G. Ossowska et al., "Brain monoamine receptors in a chronic unpredictable stress model in rats", J NEURAL TR, 108(3), 2001, pp. 311-319

Abstract

Antidepressant drugs are devoid of mood-elevating effects in normal (non-depressed) human subjects, thus, it is necessary to evaluate the antidepressant property of compounds (drugs) in animal models of depression. Several animal models of depression have been introduced, however, only a few have been extensively validated. In the present study we report the results of investigations into monoaminergic receptors in the brain of rats subjected tochronic unpredictable stress (CUS) procedure (one of the well validated animal models of depression). We have examined the dopaminergic (D-l, D-2), adrenergic (alpha -1, beta -1) and serotonergic (5HT-1A, 5HT-2A) receptors in different brain regions by a saturation radioligand binding method in rats subjected to CUS paradigm and control animals. CUS procedure resulted in a significant 29% increase in the D-l receptor density in the limbic systemand 52% increase of the density of 5HT-2A receptors in the cerebral cortex. The present data indicate that the increase of the density of brain D-l and 5HT-2A receptors of rats subjected to CUS might be involved in the pathophysiology of "animal depression" (since chronic antidepressant treatment produced opposite changes i.e. decrease in the density of these receptors) and thus in pathophysiology of human depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:09:02