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Titolo:
Differential mobilization of CD34(+) cells and lymphoma cells in non-Hodgkin's lymphoma patients mobilized with different growth factors
Autore:
Gazitt, Y; Shaughnessy, P; Liu, Q;
Indirizzi:
Univ Texas, Hlth Sci Ctr, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 th Sci Ctr, San Antonio, TX 78284 USA Wilford Hall USAF Med Ctr, San Antonio, TX 78284 USA Wilford Hall USAF MedCtr San Antonio TX USA 78284 Antonio, TX 78284 USA
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 1, volume: 10, anno: 2001,
pagine: 167 - 176
SICI:
1525-8165(200102)10:1<167:DMOCCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; BLOOD STEM-CELLS; HEMATOPOIETIC PROGENITOR CELLS; FACTOR G-CSF; HIGH-DOSE CHEMOTHERAPY; BCL-2 PROTEIN EXPRESSION; CLONAL MYELOMA CELLS; PERIPHERAL-BLOOD; PROGNOSTIC-SIGNIFICANCE; MULTIPLE-MYELOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gazitt, Y Univ Texas, Hlth Sci Ctr, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 78284 USA
Citazione:
Y. Gazitt et al., "Differential mobilization of CD34(+) cells and lymphoma cells in non-Hodgkin's lymphoma patients mobilized with different growth factors", J HEMATH ST, 10(1), 2001, pp. 167-176

Abstract

Co-mobilization of CD34(+) cells and tumor has been documented in patientswith different types of cancer undergoing peripheral blood stem cell transplantation (PBSCT). Conflicting reports were published regarding the role of various growth factors in tumor cells mobilization, hence we studied the extent of CD34(+) cells and lymphoma cell mobilization in 35 non-Hodgkin's (NHL) patients primed by cyclophosphamide (Cy) in combination with granulocyte colony-stimulating factor (GCSF) (A, 13 patients), granulocyte-macrophage (GM)-CSF (B, 10 patients), or GM-CSF followed by G-CSF (C, 12 patients). CD34(+) cells were quantitated by flow cytometry and lymphoma cells by theTaqMan Real Time PCR for bcl-2 gene rearrangement. Successful collection in 4 days of greater than or equal to2 x 10(6) CD34(+) cells/kg needed for prompt engraftment was obtained in 76%, 60%, and 58% of patients in arms A, B, and C, respectively. Lymphoma cell mobilization was detected in 35% patients tested, 78% of which had follicular lymphoma. Lymphoma cell mobilization was similar in the three arms of the study, however, presence of lymphoma cells was prevalent in patients who failed to mobilize the amount of 0.4 x 10(6) CD34(+) cells/kg in 2 days ("poor mobilizers") and reached 42%, compared to 17% in the "successful mobilizers" group of patients. Lymphoma cell contamination in PBSCs was detected proportionately in the peripheral blood and in the bone marrow. We conclude that bcl-2 gene rearrangement is prevalent in patients with follicular histology, and, in these patients, an inverse relationship was observed between mobilization of CD34(+) cells and lymphoma cells. Our results explain the high relative risk (1.98) for mobilization in patients with follicular histology.

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Documento generato il 23/01/20 alle ore 04:04:15