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Titolo:
Effects of vascular endothelial growth factor on acute myelogenous leukemia blasts
Autore:
Foss, B; Mentzoni, L; Bruserud, O;
Indirizzi:
Univ Bergen, Inst Med, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 Bergen, Inst Med, N-5021 Bergen, Norway Haukeland Univ Hosp, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 niv Hosp, N-5021 Bergen, Norway
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 1, volume: 10, anno: 2001,
pagine: 81 - 93
SICI:
1525-8165(200102)10:1<81:EOVEGF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; PERMEABILITY FACTOR; IN-VITRO; VEGF-C; CELL GROWTH; ANGIOGENESIS; EXPRESSION; RECEPTORS; TRANSPLANTATION; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bruserud, O Univ Bergen, Inst Med, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 Med, N-5021 Bergen, Norway
Citazione:
B. Foss et al., "Effects of vascular endothelial growth factor on acute myelogenous leukemia blasts", J HEMATH ST, 10(1), 2001, pp. 81-93

Abstract

Vascular endothelial growth factor (VEGF) and its specific receptors are expressed by various malignant cells, including acute myelogenous leukemia (AML) blasts. In this study we performed a detailed characterization of VEGFeffects on native human AML blasts derived from a large group of consecutive AML patients with high blast counts in peripheral blood. Exogenous VEGF had divergent effects on spontaneous proliferation and cytokine-dependent (GM-CSF, G-CSF, IL-3) proliferation. Increased, decreased, or unaltered proliferation was observed in the presence of VEGF for various patients, and the VEGF effect differed even in the same patient depending on which exogenous cytokine being present together with VEGF. Similarly, increased, decreased or unaltered interleukin-1 beta (IL-1 beta) and IL-6 secretion was detected when VEGF was added, and for certain patients the effect of VEGF differed between IL-1 beta and IL-6. Exogenous VEGF could also modulate proliferation and differentiation of clonogenic AML progenitors. Constitutive AML blast secretion of VEGF was detected for 40% of patients. Leptin, Flt3-L, IL-4, IL-10, and IL-13 had divergent effects on VEGF release by AML blasts. These results suggest that VEGF can modulate AML blast functions in vivo for asubset of patients. Furthermore, the detection of VEGF in peripheral bloodstem cell (PBSC) autografts suggests that VEGF may influence the proliferation and possibly also the survival of contaminating AML cells in PBSC autografts. We conclude that VEGF may influence the functional characteristics of AML cells. Our results suggest that VEGF is important in leukemic hematopoiesis, and the detection of VEGF in PBSC autografts indicates that VEGF may influence the functional phenotype of contaminating AML cells in these grafts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:41:23