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Titolo:
Macrophage death and the role of apoptosis in human atherosclerosis
Autore:
Hegyi, L; Hardwick, SJ; Siow, RCM; Skepper, JN;
Indirizzi:
Addenbrookes Hosp, ACCI, Dept Med, Div Cardiovasc Med, Cambridge CB2 2QQ, England Addenbrookes Hosp Cambridge England CB2 2QQ , Cambridge CB2 2QQ, England Univ Cambridge, Dept Anat, Sch Biol Sci, Multi Imaging Ctr, Cambridge, England Univ Cambridge Cambridge England Multi Imaging Ctr, Cambridge, England Univ Cambridge, Dept Pathol, Cambridge, England Univ Cambridge CambridgeEngland ridge, Dept Pathol, Cambridge, England
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 1, volume: 10, anno: 2001,
pagine: 27 - 42
SICI:
1525-8165(200102)10:1<27:MDATRO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE CELLS; CORONARY-ARTERY DISEASE; HUMAN MONOCYTE-MACROPHAGES; HUMAN ENDOTHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; DNA-POLYMERASE-DELTA; HERITABLE HYPERLIPIDEMIC RABBITS; MANGANESE SUPEROXIDE-DISMUTASE; AMERICAN-HEART-ASSOCIATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
191
Recensione:
Indirizzi per estratti:
Indirizzo: Hegyi, L Addenbrookes Hosp, ACCI, Dept Med, Div Cardiovasc Med, Hills Rd, CambridgeCB2 2QQ, England Addenbrookes Hosp Hills Rd Cambridge England CB22QQ QQ, England
Citazione:
L. Hegyi et al., "Macrophage death and the role of apoptosis in human atherosclerosis", J HEMATH ST, 10(1), 2001, pp. 27-42

Abstract

The arterial disease atherosclerosis is responsible for severe morbidity and is the most common cause of death in the Western population. The complete pathogenesis of the disease is unknown, but multiple risk factors have been identified that correlate with the development of its complications suchas heart attack and stroke. Evidence suggests that atherosclerosis is an inflammatory disease and the major cell types involved are smooth muscle cells, macrophages, and T lymphocytes. In this paper, we review the function of macrophages in the context of atherosclerosis and we also discuss the role and significance of macrophage death, including apoptosis. There is much evidence, certainly in vitro, suggesting that low-density lipoprotein becomes atherogenic when it undergoes cell-mediated oxidation within the artery wall. Besides inducing apoptosis in vitro, oxidized low-density lipoproteinmay also cause extensive DNA damage in intimal cells, which might presage apoptosis. We review the results of experimental and clinical studies, which may indicate how the complications of atherosclerosis could be prevented by using different therapeutical strategies including bone marrow transplantation and gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 01:40:16