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Titolo:
Cellular localisation of GH receptor in the bovine mammary gland during mammogenesis, lactation and involution
Autore:
Sinowatz, F; Schams, D; Kolle, S; Plath, A; Lincoln, D; Waters, MJ;
Indirizzi:
Univ Munich, Lehrstuhl Tieranat 2, Inst Vet Anat, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 nst Vet Anat, D-80539 Munich, Germany Tech Univ Munich, Inst Physiol, D-8530 Freising, Germany Tech Univ MunichFreising Germany D-8530 ysiol, D-8530 Freising, Germany Kuwait Univ, Fac Allied Hlth Sci, Kuwait, Kuwait Kuwait Univ Kuwait Kuwait ait Univ, Fac Allied Hlth Sci, Kuwait, Kuwait
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 166, anno: 2000,
pagine: 503 - 510
SICI:
0022-0795(200009)166:3<503:CLOGRI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE RECEPTOR; MESSENGER-RIBONUCLEIC-ACID; SERUM BINDING-PROTEIN; GENE-EXPRESSION; FACTOR-I; LIVER; SOMATOTROPIN; PROLACTIN; TISSUE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sinowatz, F Univ Munich, Lehrstuhl Tieranat 2, Inst Vet Anat, Marchioninistr 15, D-80539 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-80539 Germany
Citazione:
F. Sinowatz et al., "Cellular localisation of GH receptor in the bovine mammary gland during mammogenesis, lactation and involution", J ENDOCR, 166(3), 2000, pp. 503-510

Abstract

We have used immunohistochemistry and non-radioactive in situ hybridisation to localise the GH receptor and its transcript in the bovine mammary gland during mammogenesis, lactation and involution. We found a characteristic pattern of immunoreactive GH (irGH) receptor distribution in the epithelialand stromal compartments during the different stages of mammary gland development: The ductular epithelium showed a distinct staining for irGH receptor during most stages, whereas the alveolar epithelium contained a modest amount of GH receptor during pregnancy which increased during lactation and galactopoiesis. In dry cows, the immunostaining for GH receptors in the alveolar epithelium was very weak or negative. Curiously, the amount of GH receptor mRNA appeared relatively constant during mammogenesis and lactation. The epithelial cells of the alveoli and ducts as well as the endothelial cells showed a distinct signal in our in situ hybridisation studies. The predominant localisation of GH receptors in the epithelium of ducts and alveoliis supportive of a role for GH in epithelial differentiation and maintenance. Furthermore, the increased intensity of immunostaining in bovine mammary tissue post partum suggests a direct role for GH receptor in mediating the effect of GH in milk production and secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:31:23