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Titolo:
Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: Sobering results
Autore:
Breathnach, OS; Freidlin, B; Conley, B; Green, MR; Johnson, DH; Gandara, DR; OConnell, M; Shepherd, FA; Johnson, BE;
Indirizzi:
Dana Farber Canc Inst, Thorac Oncol Program, Lowe Ctr Thorac Oncol, Dept Adult Oncol, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115ult Oncol, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA USA Harvard Univ Boston MA USA rvard Univ, Sch Med, Dept Med, Boston, MA USA NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Biometr Res Branch,Clin Invest Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 anch,Clin Invest Branch, Bethesda, MD 20892 USA Canc & Leukemia Grp B, Chicago, IL USA Canc & Leukemia Grp B Chicago IL USA c & Leukemia Grp B, Chicago, IL USA Eastern Cooperat Oncol Grp, Pittsburgh, PA USA Eastern Cooperat Oncol GrpPittsburgh PA USA col Grp, Pittsburgh, PA USA SW Oncol Grp, San Antonio, TX USA SW Oncol Grp San Antonio TX USASW Oncol Grp, San Antonio, TX USA N Cent Canc Treatment Grp Philadelphia, Philadelphia, PA USA N Cent Canc Treatment Grp Philadelphia Philadelphia PA USA lphia, PA USA Natl Canc Inst, Canada Clin Trials Grp, Kingston, ON, Canada Natl Canc Inst Kingston ON Canada Clin Trials Grp, Kingston, ON, Canada
Titolo Testata:
JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 6, volume: 19, anno: 2001,
pagine: 1734 - 1742
SICI:
0732-183X(20010315)19:6<1734:TYOPIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOUTHWEST-ONCOLOGY-GROUP; VINDESINE PLUS CISPLATIN; RANDOMIZED TRIAL; COMBINATION CHEMOTHERAPY; BRONCHOGENIC-CARCINOMA; SINGLE-AGENT; MITOMYCIN-C; DOXORUBICIN; CYCLOPHOSPHAMIDE; REGIMENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Breathnach, OS Dana Farber Canc Inst, Thorac Oncol Program, Lowe Ctr Thorac Oncol, Dept Adult Oncol, Ste 1234,44 Binney St, Boston, MA 02115 USA DanaFarber Canc Inst Ste 1234,44 Binney St Boston MA USA 02115
Citazione:
O.S. Breathnach et al., "Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: Sobering results", J CL ONCOL, 19(6), 2001, pp. 1734-1742

Abstract

Purpose: To determine the changes in clinical trials and outcomes of patients with advanced-stage nonsmall-cell lung cancer (NSCLC) treated on phase III randomized trials initiated in North America from 1973 to 1994,Patients and Methods: Phase III trials for patients with advanced-stage NSCLC were identified through a search of the National Cancer Institute's Cancer Therapy Evaluation Program database from 1973 to 1994, contact with Cooperative Groups, and by literature search of MEDLINE. Patients with advanced NSCLC treated during a similar time interval were also examined in the SEER database. Trends were tested in the number of trials, in the number and sex of patients entered on the trials, and in survival over time,Results: Thirty-three phase III trials were initiated between 1973 and 1994. Twenty-four trials (73%) were initiated within the first half of this period (1973 to 1983) and accounted for 5,359 (64%) of the 8,434 eligible patients. The median number of patients treated per arm of the trials rose from 77 (1973 to 1983) to 121 (1984 to 1994) (P < .001). five trials (15%) showed a statistically significant difference in survival between treatment arms, with a median prolongation of the median survival of 2 months (range, 0.7 to 2.7 months). Conclusion: Analysis of past trials in North America shows that the prolongation in median survival between two arms of a randomized study was rarelyin excess of 2 months. Techniques for improved use of patient resources and appropriate trial design for phase III randomized therapeutic trials withpatients with advanced NSCLC need to be developed. <(c)> 2001 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:12:13