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Titolo:
Comparison of the effects on drug concentrations, electrophysiologic parameters, and termination of atrial fibrillation in dogs when procainamide andibutilide are delivered into the right atrium versus intravenously
Autore:
Vereckei, A; Warman, E; Mehra, R; Zipes, DP;
Indirizzi:
Indiana Univ, Med Ctr, Krannert Inst Cardiol, Sch Med,Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Medtron Inc, Minneapolis, MN USA Medtron Inc Minneapolis MN USAMedtron Inc, Minneapolis, MN USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 330 - 336
SICI:
1045-3873(200103)12:3<330:COTEOD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUS RHYTHM; EFFICACY; CONVERSION; INFUSION; DETERMINANTS; FLUTTER;
Keywords:
right intra-atrial drug delivery; intravenous drug delivery; ibutilide; procainamide; atrial fibrillation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Zipes, DP Indiana Univ, Med Ctr, Krannert Inst Cardiol, Sch Med,Dept Med, 1111 W 10th St, Indianapolis, IN 46202 USA Indiana Univ 1111 W 10th St Indianapolis IN USA 46202 46202 USA
Citazione:
A. Vereckei et al., "Comparison of the effects on drug concentrations, electrophysiologic parameters, and termination of atrial fibrillation in dogs when procainamide andibutilide are delivered into the right atrium versus intravenously", J CARD ELEC, 12(3), 2001, pp. 330-336

Abstract

Introduction: We tested the hypothesis that right intra-atrial (IA) administration of antiarrhythmic drugs resulted in higher peak serum drug concentrations, greater electrophysiologic effects, and greater efficacy for termination of atrial fibrillation (AF) than intravenous (IV) drug delivery. Methods and Results: Eight dogs were treated with 9.7 mg/kg procainamide infusion and eight dogs with 0.02 mg/kg ibutilide infusion, injected over 5 minutes. Each dog had both an electrophysiologic (EP) and an AF terminationstudy during IA and IV drug administration at greater than or equal to2-day intervals (total four studies each). Right atrial pacing capture threshold, right atrial effective refractory period (ERP), right atrial and right ventricular monophasic action potential (MAP) durations at 70% and 90% of repolarization (MAPD(70), MAPD(90)), AH, HV, and QT intervals, QRS width, intra-arterial systolic and diastolic blood pressures, and cardiac output weremeasured at different time-points. Blood samples were drawn from the coronary sinus and femoral vein for drug level determination. The right atrium was paced at 400-msec cycle length throughout the study. AF was induced by rapid right atrial pacing and maintained by methacholine infusion at 1.5 to 3 mug/kg/min. The sustained AF was allowed to persist for 10 minutes beforestarting the antiarrhythmic drug infusion. We found no significant difference between the procainamide concentrations in the coronary sinus and femoral vein during IA and IV drug delivery. The time course and extent of increase in right atrial ERP, MAPD(70), MAPD(90), and all the other measured EP parameters did not differ between the two routes of drug administration, Nosignificant difference was found in termination of AF between IV (5/7 procainamide; 4/8 ibutilide) or IA (3/8 procainamide; 3/8 ibutilide) drug delivery or between drugs (8/15 procainamide; 7/16 ibutilide). Conclusion: Our data do not support any beneficial effect of IA versus IV procainamide or ibutilide delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:41:32