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Titolo:
Breakthrough waves during ventricular fibrillation depend on the degree ofrotational anisotropy and the boundary conditions: A simulation study
Autore:
Ashihara, T; Namba, T; Ikeda, T; Ito, M; Kinoshita, M; Nakazawa, K;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 1, Otsu, Shiga 5202192, Japan Kagawa Prefectural Coll Hlth Sci, Dept Med Technol, Kita, Japan Kagawa Prefectural Coll Hlth Sci Kita Japan pt Med Technol, Kita, Japan Toho Univ, Sch Med, Dept Internal Med 3, Tokyo, Japan Toho Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 3, Tokyo, Japan Natl Cardiovasc Ctr, Res Inst, Dept Epidemiol, Suita, Osaka 565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 565 demiol, Suita, Osaka 565, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 312 - 322
SICI:
1045-3873(200103)12:3<312:BWDVFD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL CONTINUOUS MYOCARDIUM; CARDIAC FIBRILLATION; FIBER ROTATION; MODEL; MECHANISM; MUSCLE; HEART; ARRHYTHMIAS; DYNAMICS; REPOLARIZATION;
Keywords:
ventricular fibrillation; rotational anisotropy; scroll wave; transmural reentry; breakthrough wave; computer simulation; Luo-Rudy phase I model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ashihara, T Shiga Univ Med Sci, Dept Internal Med 1, Tsukinowa Cho, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Tsukinowa Cho Otsu Shiga Japan 5202192 apan
Citazione:
T. Ashihara et al., "Breakthrough waves during ventricular fibrillation depend on the degree ofrotational anisotropy and the boundary conditions: A simulation study", J CARD ELEC, 12(3), 2001, pp. 312-322

Abstract

Introduction: The left ventricle (LV) and right ventricle (RV) are characterized by specific fiber orientation known as "rotational anisotropy. " However, it remains unclear whether the LV and RV are different with regard to the effect of rotational anisotropy on the dynamics of scroll waves during ventricular fibrillation (VF). To resolve this issue, we used a computation-based model to study scroll wave behavior. Methods and Results: We composed an environment of simulated three-dimensional ventricular wall slabs, with optional ratios of fiber rotation to wallthickness (0 degrees, 6 degrees, and 12 degrees /mm thickness; LV 10 mm, RV 5 mm), using Luo-Rudy phase I equations. When rotational anisotropy was not incorporated into the LV wall slab (theta endo similar to theta epi = 0 degrees), most scroll waves rotated around the filaments perpendicular to the tissue surface, with only a few accompanying breakthrough waves. In a twisted LV model (theta endo similar to theta epi = 60 degrees and 120 degrees), the scroll waves were demonstrated as multiple wavelets scattered spatiotemporally, frequently accompanied by breakthrough waves that were promoted by rotational anisotropy, In a twisted RV model (theta endo similar to theta epi = 30 degrees and 60 degrees), single scroll waves and/or figure-of-eight reentrant waves appeared, with comparatively few breakthrough waves, regardless of the degree of fiber twist. Conclusion: The proportion of electrical effects of rotational anisotropy and tissue boundaries plays an important role in the genesis of breakthrough waves during VF, and the difference in wave propagating patterns and frequency spectrum of the ventricles may arise, in part, from the number of breakthrough waves promoted by rotational anisotropy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:37:32