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Titolo:
Inflammatory markers in major depression and melancholia
Autore:
Rothermundt, M; Arolt, V; Peters, M; Gutbrodt, H; Fenker, J; Kersting, A; Kirchner, H;
Indirizzi:
Univ Munster, Dept Psychiat & Psychotherapy, D-48129 Munster, Germany UnivMunster Munster Germany D-48129 hotherapy, D-48129 Munster, Germany Univ Luebeck, Sch Med, Inst Immunol & Transfus Med, Lubeck, Germany Univ Luebeck Lubeck Germany nst Immunol & Transfus Med, Lubeck, Germany
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1-3, volume: 63, anno: 2001,
pagine: 93 - 102
SICI:
0165-0327(200103)63:1-3<93:IMIMDA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE PROTEINS; CIRCULATING NATURAL-KILLER; CYTOKINE PRODUCTION; LYMPHOCYTE SUBSETS; IMMUNE ACTIVATION; PLASMA-PROTEINS; CELLS; DISTURBANCES; HAPTOGLOBIN; DISORDERS;
Keywords:
major depression; melancholia; immunology; cytokines; acute phase proteins; monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Rothermundt, M Univ Munster, Dept Psychiat & Psychotherapy, Albert Schweitzer Str 11, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 11 Munster Germany D-48129
Citazione:
M. Rothermundt et al., "Inflammatory markers in major depression and melancholia", J AFFECT D, 63(1-3), 2001, pp. 93-102

Abstract

Background: Then is evidence that patients with major depression (MD) alsosuffer an inflammatory immune reaction. However, the results remain ambiguous. This could be due to the psychiatrically heterogeneous patient samplesinvestigated in many published studies. Since melancholic depression is psychopathologically and possibly etiologically different from non-melancholic MD, we focused on investigating immune parameters in these two subgroups. Methods: 43 in-patients suffering from acute major depression were diagnosed, sub-classified according to DSM IV criteria, and compared to 43 matchedhealthy controls. Cell counts were determined by morphology, and acute phase proteins [c-reactive protein (CRP), alpha (2)-macroglobulin (A2M), haptoglobin (HP)] were measured by laser nephelometry. Cytokine production (IL-1beta upon mitogen stimulation was measured by ELISA in a whole blood assay. Results: Non-melancholic patients showed increased monocyte counts and A2M serum concentrations in the acute stage of disease and after 2 and 4 weeks of treatment. Melancholic patients demonstrated a decreased monocyte count upon admission and after 4 weeks of treatment. HP levels and IL-1 beta production were unchanged in all studied subjects. Limitations: Medication ofthe patients varied. The differentiation between melancholic and non-melancholic depression was performed clinically and was not performed using any standardized instrument. Conclusion: Melancholic and non-melancholic patients show different immune patterns. This differentiation might clarify immunological findings in MD and point towards etiological factors that are involved in the development of various subtypes of MD. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 01/04/20 alle ore 01:19:34