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Titolo:
Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile
Autore:
Sawano, M; Watanabe, Y; Ohmura, H; Shimada, K; Daida, H; Mokuno, H; Yamaguchi, H;
Indirizzi:
Juntendo Univ, Dept Cardiol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 tendo Univ, Dept Cardiol, Tokyo 113, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 4, volume: 65, anno: 2001,
pagine: 310 - 314
SICI:
0047-1828(200104)65:4<310:PPEOTS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC LIPASE; DNA POLYMORPHISMS; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY; HDL CHOLESTEROL; LPL GENE; ASSOCIATIONS; MEN; LDL; HYPERTRIGLYCERIDEMIA;
Keywords:
coronary artery disease; high-density lipoprotein; lipoprotein lipase; Ser447-Ter mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sawano, M Int Goodwill Hosp, Dept Cardiol, Izumi Ku, 1-28-1 Nishigaoka, Yokohama, Kanagawa 2450006, Japan Int Goodwill Hosp 1-28-1 Nishigaoka Yokohama Kanagawa Japan 2450006
Citazione:
M. Sawano et al., "Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile", JPN CIRC J, 65(4), 2001, pp. 310-314

Abstract

Several DNA variants at the lipoprotein lipase (LPL) gene locus have been found to be associated with the plasma lipid levels and the prevalence of coronary artery disease (CAD). In particular, the Ser447-termination (Ter) mutation at the exon 9 of the LPL gene has the potential to elevate the plasma high-density lipoprotein (HDL) levels, but it remains unknown in the Japanese population. The present study investigated 93 CAD patients and 96 age- and sex-matched healthy controls. The Ser447-Ter mutation was determined by polymerase chain reaction restriction fragment length polymorphism method. The allelic frequency of the Ser447-Ter mutation was 0.103 in all subjects. The Ser447-Ter (GG and CG) group was associated with significantly higher levels of plasma HDL-cholesterol (p<0.001) and lower levels of plasma triglyceride than the CC group (p<0.02). The peak particle size of low-density lipoprotein (LDL) was significantly larger in the Ser447-Ter (GG and CG) group than in CC group (p<0.05). The frequency of the Ser447-Ter genotype in GG and CG was significantly lower in CAD than in the controls (11.9% vs 26%, odds ratio = 0.38; 95% confidence interval, 0.18-0.81; p<0.02). These results suggest that the Ser447-Ter mutation of the LPL gene is associated with high plasma HDL-cholesterol levels, low plasma triglyceride levels and a larger LDL particle size. This mutation may have a protective effect against the development of CAD via its favorable lipoprotein profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:30:30