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Titolo:
Psychopharmacological challenge studies in psychiatric research
Autore:
DSouza, DC; Krystal, JH;
Indirizzi:
W Haven Vet Affairs Med Ctr, Schizophrenia Biol Res Ctr, W Haven, CT USA WHaven Vet Affairs Med Ctr W Haven CT USA Biol Res Ctr, W Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Neurol, New Haven, CT 06510 USA
Titolo Testata:
INTERNATIONAL REVIEW OF PSYCHIATRY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 40 - 46
SICI:
0954-0261(200102)13:1<40:PCSIPR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA; AMPHETAMINE; KETAMINE; PSYCHOSIS; METHYLPHENIDATE; PROVOCATION; SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: D'Souza, DC VA Connecticut Healthcare Syst, Psychiat Serv 116A, 950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 950 Campbell Ave W Haven CT USA 06516
Citazione:
D.C. D'Souza e J.H. Krystal, "Psychopharmacological challenge studies in psychiatric research", INT R PSYC, 13(1), 2001, pp. 40-46

Abstract

Psychopharmacological challenge studies have made significant contributions to understanding the neurobiological basis of psychiatric disorders. Withthe emergence of novel, sometimes alternative, techniques to study the neurobiology of psychiatric disorders, and the risks associated with some psychopharmacological challenge studies, the role of this technique has come under increasing scrutiny. Using the psychostimulant paradigm in schizophrenia research as the prototypical study, the important scientific contributions and risks of psychopharmacological challenge studies will be reviewed. The historical contributions of psychopharmacological challenge studies to psychiatric research will be reviewed. The risks and benefits of this approach will then be reviewed, in particular within the current ethical standards. Finally, the future role of psychopharmacological challenge studies is discussed. In the foreseeable future, psychopharmacological challenge studieseither alone or in conjunction with novel techniques such as brain imaging, may continue to provide an important method to test candidate pathophysiologic mechanisms and to study potential pharmacotherapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:23:49