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Titolo:
Immunohistochemical expression of P-glycoprotein in the rat urinary bladder and the effect of verapamil on intravesical chemotherapy
Autore:
Hashimoto, H; Tokumitsu, M; Saga, Y; Okuyama, M; Yachiku, S;
Indirizzi:
Asahikawa Med Coll, Dept Urol, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF UROLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 118 - 123
SICI:
0919-8172(200103)8:3<118:IEOPIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA CELL-LINE; MULTIDRUG-RESISTANCE; ESTABLISHMENT; VINBLASTINE; DOXORUBICIN; ABSORPTION; EFFLUX; CANCER; GENE;
Keywords:
bladder tumor; intravesical chemotherapy; multidrug resistance; P-glycoprotein; verapamil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, H Asahikawa Med Coll, Dept Urol, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll 2-1-1-1 Midorigaoka Higashi Asahikawa Hokkaido Japan 0788510
Citazione:
H. Hashimoto et al., "Immunohistochemical expression of P-glycoprotein in the rat urinary bladder and the effect of verapamil on intravesical chemotherapy", INT J UROL, 8(3), 2001, pp. 118-123

Abstract

Background: The expression of P-glycoprotein (Pgp) is thought to be commonin bladder epithelium and the multidrug resistance mediated by Pgp must beconsidered to improve the efficacy of chemotherapy for bladder tumors. Methods: The expression of Pgp in normal and tumor tissue of the rat urinary bladder was first examined immunohistochemically. The effect of verapamil, an expected modulator of Pgp, on intravesical chemotherapy of the rats was then investigated. Results: Pgp was immunohistochemically detected in normal epithelium and in tumor tissue of the rat urinary bladder. In those normal and tumor-bearing bladders, verapamil promoted the uptake of intravesically instilled pirarubicin, but the efflux of intracellular accumulated pirarubicin was observed subsequently in both conditions with and without verapamil. The drug concentration decreased more rapidly in the verapamil group than in the controlgroup. Conclusions: Verapamil is thought to be useful in promoting uptake of intravesically instilled pirarubicin, but it did not appear to be so efficient at limiting the efflux of intracellular accumulated pirarubicin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:28:35