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Titolo:
Interrelationship between insulin, leptin and growth hormone in growth hormone-treated children
Autore:
Zadik, Z; Wittenberg, I; Segal, N; Altman, Y; Zung, A; Gross, V; Reifen, R;
Indirizzi:
Kapiolani Med Ctr, Pediat Endocrine Unit, IL-76100 Rehovot, Israel Kapiolani Med Ctr Rehovot Israel IL-76100 Unit, IL-76100 Rehovot, Israel Shaare Zedek Hosp, Neurol Unit, Rehovot, Israel Shaare Zedek Hosp Rehovot Israel dek Hosp, Neurol Unit, Rehovot, Israel Hebrew Univ Jerusalem, Sch Nutr Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 538 - 542
SICI:
0307-0565(200104)25:4<538:IBILAG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
24-HOUR INTEGRATED CONCENTRATION; PRADER-WILLI-SYNDROME; I IGF-I; PLASMA LEPTIN; BODY-COMPOSITION; BINDING-PROTEIN; OBESE GENE; GLUCOSE-TOLERANCE; ANOREXIA-NERVOSA; ADIPOSE-TISSUE;
Keywords:
obesity; Prader-Willi syndrome; growth hormone; growth hormone-binding protein; insulin; leptin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Zadik, Z Kapiolani Med Ctr, Pediat Endocrine Unit, IL-76100 Rehovot, Israel Kapiolani Med Ctr Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
Z. Zadik et al., "Interrelationship between insulin, leptin and growth hormone in growth hormone-treated children", INT J OBES, 25(4), 2001, pp. 538-542

Abstract

OBJECTIVES: The aim of the study was to examine insulin homeostasis duringgrowth hormone (GH) therapy, and to investigate the effect of GH treatmenton insulin and leptin concentration in obese children. SUBJECTS: Nineteen obese children (8 with Prader-Willi Syndrome (PWS)) were treated with GH 0.1IU/kg/day dose for 3 months and were compared with 29 non-treated age and sex matched obese children (9 PWS) and 49 GH treated non-obese short children. Mean age of the children was 10.3 +/- 1.8 (6.7 - 1 3.8) y, with body mass index of 23.6 +/- 1 0.4 (11.5 -47) kg/m(2)RESULTS: leptin concentration decreased acid was correlated inversely withinitial leptin value (r(2) = - 0.374, P < 0.001) and decreased body mass (r(2) = 0.338, P= 0.001). Insulin sensitivity index was not significantly changed during therapy. Leptin decrease after 3 months of GH administration was correlated inversely with the increase in first phase insulin response to intravenous glucose tolerance test (IVGTT) (r(2)=-0.595, P < 0.001). Results of long-term follow-up of treated patients demonstrated a decrease in insulin concentration after cessation of therapy. In GH-treated subjects, the glucose increase in response to glucose load appeared to be higher than in untreated subjects. CONCLUSION: The high insulin response to glucose load seen in GH-treated subjects was appropriate to their glucose concentration and the insulin sensitivity index was unchanged relative to the pretreatment period. Increased insulin dosage in our patients did not induce an increase in leptin concentrations as had been hypothesised.

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Documento generato il 25/01/20 alle ore 09:21:20