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Titolo:
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
Autore:
Buemann, B; Schierning, B; Toubro, S; Bibby, BM; Sorensen, T; Dalgaard, L; Pedersen, O; Astrup, A;
Indirizzi:
Royal Vet & Agr Univ, Res Dept Human Nutr, DK-1958 Frederiksberg, Denmark Royal Vet & Agr Univ Frederiksberg Denmark DK-1958 rederiksberg, Denmark Royal Vet & Agr Univ, Math Sect, Frederiksberg, Denmark Royal Vet & Agr Univ Frederiksberg Denmark Sect, Frederiksberg, Denmark Copenhagen Univ Hosp, Inst Prevent Med, Danish Epidemiol Sci Ctr, Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark ol Sci Ctr, Copenhagen, Denmark Steno Diabet Ctr, DK-2820 Gentofte, Denmark Steno Diabet Ctr Gentofte Denmark DK-2820 Ctr, DK-2820 Gentofte, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 467 - 471
SICI:
0307-0565(200104)25:4<467:TABTVP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; BROWN ADIPOSE-TISSUE; ENERGY-EXPENDITURE; SKELETAL-MUSCLE; METABOLIC-RATE; UP-REGULATION; PIMA-INDIANS; BODY-WEIGHT; OBESITY; UCP3;
Keywords:
bicycling; energy expenditure; exercise efficiency; oxygen uptake; polymorphism; uncoupling proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Buemann, B Royal Vet & Agr Univ, Res Dept Human Nutr, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark Royal Vet & Agr Univ Rolighedsvej 30 Frederiksberg Denmark DK-1958
Citazione:
B. Buemann et al., "The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency", INT J OBES, 25(4), 2001, pp. 467-471

Abstract

BACKGROUND: Energy expenditure may partly be determined by genetic variations in uncoupling proteins. We have previously found an increased physical activity but a similar 24-h energy expenditure (EE) in subjects with the val/val-55 UCP2 genotype compared to those with the ala/ala genotype which indicates that the val-55 allele is statistically associated with a higher metabolic efficiency. DESIGN: EE during bicycling was determined by indirect calorimetry at three different loads (30, 40 and 60% of VO2max in eight subjects with the val/val-55 genotype (35 +/- 6 y weight = 76.8 +/- 13.6 kg, VO2max = 2.79 +/- 0.71 l/min) and eight subjects with the ala/ala-55 genotype (37 +/- 3 y, weight = 78.3 +/- 16.5 kg, VO2max = 2.66 +/- 0.41 l/min). RESULTS: Incremental exercise efficiency across the three different work levels was higher in the val/val (25.3%, c.i. 24.2-26.4%) than in the ala/ala (23.6%, c.i. 22.5-24.7%) genotype P < 0.05. Cross exercise efficiency at 40% VO2max was higher in the val/val (15.3 <plus/minus> 0.6%) than in the ala/ala (13.5 +/- 0.4%) group. CONCLUSION: As the val/ala-55 polymorphism is located in a domain of the protein without any known function, the different exercise efficiency between the two genotypes most likely reflects a linkage disequilibrium with a functionally significant polymorphism in UCP2 or in the neighbouring UCP3 gene. The study suggests that variations in the UCP genes may affect not only basal metabolic rate but also influence energy costs of exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 16:00:04