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Titolo:
Bax expression as a prognostic marker of postoperative chemoradiotherapy for patients with esophageal cancer
Autore:
Ikeguchi, M; Maeta, M; Kaibara, N;
Indirizzi:
Tottori Univ, Fac Med, Dept Surg 1, Yonago, Tottori 6838504, Japan TottoriUniv Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 413 - 417
SICI:
1107-3756(200104)7:4<413:BEAAPM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR P53; CYTOCHROME-C; LYMPH-NODE; GENE BAX; CARCINOMA; APOPTOSIS; CHEMOTHERAPY; MITOCHONDRIA; RADIOTHERAPY; MUTATION;
Keywords:
esophageal squamous cell carcinoma; adjuvant chemoradiotherapy; Bax; p53; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeguchi, M Tottori Univ, Fac Med, Dept Surg 1, Nishi Cho 36-1, Yonago, Tottori 6838504, Japan Tottori Univ Nishi Cho 36-1 Yonago Tottori Japan 6838504 Japan
Citazione:
M. Ikeguchi et al., "Bax expression as a prognostic marker of postoperative chemoradiotherapy for patients with esophageal cancer", INT J MOL M, 7(4), 2001, pp. 413-417

Abstract

Postoperative chemoradiotherapy was introduced to improve the survival of patients with esophageal squamous cell carcinoma (ESCC). However, considerable number of patients still die of cancer recurrence despite curative operation plus chemoradiotherapy. This indicates that some ESCCs are chemoradio-resistant. To prevent unnecessary treatment and to improve the effect of post-operative adjuvant therapy, it seems to be important to investigate biological markers of chemoradio-sensitivity in ESCC. Loss of Bax expression has been reported to be associated with poor response to chemotherapy in breast cancer, and Bax promotes apoptosis in cells. Abnormal expression of Baxmay play an important role in chemoradio-sensitivity in malignant tumors. In this study, we retrospectively investigated the prognostic significance of the expressions of Fax and p53 in patients with ESCC. Immunoreactivitiesof Bax and p53 were evaluated in 141 surgically resected ESCC by using monoclonal antibodies. Prognoses of 141 patients with or without postoperativechemoradiotherapy were compared among groups with high and low expressionsof Fax or p53. High immunoreactivities of Pax and p53 were detected in 49 cases (33.1%) and in 70 cases (47.3%), respectively. Loss of Pax expressionwas detected more frequently in p53-positive tumors. Pax expression correlated with favorable prognosis (P=0.016) in 57 patients with postoperative chemoradiotherapy. However, in 84 patients without adjuvant therapy, the prognostic significance of Pax was minimal. Moreover, in patients with or without postoperative chemoradiotherapy, p53 expression did not correlate with the prognosis. Pax expression may be a good marker for chemoradio-sensitivity in patients with ESCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:32:12