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Titolo:
Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development ofthe vascular system in the chick embryo bursa of Fabricius
Autore:
Ribatti, D; De Falco, G; Vacca, A; Nico, B; Errede, M; Roccaro, AM; Roncali, L; Dammacco, F;
Indirizzi:
Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy Univ Bari Bari Italy I-70124 pt Human Anat & Histol, I-70124 Bari, Italy Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Bari, Italy Univ Bari Bari Italy ch Med, Dept Biomed Sci & Human Oncol, Bari, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 365 - 368
SICI:
1107-3756(200104)7:4<365:CITVEG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULOGENESIS; VEGF; ANGIOGENESIS; MICE;
Keywords:
angiogenesis; bursa of Fabricius; vascular endothelial growth factor; vascular endothelial growth factor receptor-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ribatti, D Univ Bari, Sch Med, Dept Human Anat & Histol, Piazza Giulio Cesare 11, I-70124 Bari, Italy Univ Bari Piazza Giulio Cesare 11 Bari Italy I-70124 ri, Italy
Citazione:
D. Ribatti et al., "Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development ofthe vascular system in the chick embryo bursa of Fabricius", INT J MOL M, 7(4), 2001, pp. 365-368

Abstract

The bursa of Fabricius is a lymphoid organ of the chick which plays an important role in the development of the immune system. The role of angiogenicfactors in the development of the Vascular system of this organ has been poorly investigated. Vascular endothelial growth factor (VEGF) is a major regulator of endothelial cell proliferation, angiogenesis and vascular permeability, and its activities are mediated by two receptors, VEGFR-1 and VEGFR-2. In this study we have investigated by immunohistochemistry the VEGF andVEGFR-2 immunoreactivity in developing bursa of Fabricius. Starting from day 10 of incubation, the endodermal epithelium reacts with VEGF and gives rise to the lymphoid follicles, while the vascular endothelium reacts with VEGFR-2. These data support the view that VEGF acts as a paracrine stimulator of angiogenesis in the avian embryo and confirm the requirement of the endodermal layer for the normal formation of blood vessels by mesodermal cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:13:17