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Titolo:
CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosis
Autore:
Nothnick, WB; Fan, F; Iczkowski, KA; Ashwell, R; Thomas, P; Tawfik, OW;
Indirizzi:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 & Lab Med, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Obstet & Gynecol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 & Gynecol, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 t Physiol, Kansas City, KS 66160 USA Reading Hosp, W Reading, PA USA Reading Hosp W Reading PA USAReading Hosp, W Reading, PA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 140 - 146
SICI:
0277-1691(200104)20:2<140:CEIRIE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS IN-VITRO; MENSTRUAL-CYCLE; E-CADHERIN; RETROGRADE MENSTRUATION; MELANOMA-CELLS; CANCER-CELLS; NUDE-MICE; INTEGRINS; MATRIX; PROLIFERATION;
Keywords:
CD44; adhesion molecules; endometriosis; endometrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Tawfik, OW Univ Kansas, Med Ctr, Dept Pathol & Lab Med, 3901 Rainbow Blvd,Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA66160 6160 USA
Citazione:
W.B. Nothnick et al., "CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosis", INT J GYN P, 20(2), 2001, pp. 140-146

Abstract

Immunohistochemical expression of the standard form of CD44 (CD44s) was examined in archival formalin-fixed endometriotic and matching eutopic endometrial tissue obtained from 25 patients in proliferative (N = 16) and secretory (N = 9) stages of the cycle. CD44s was expressed in most eutopic endometria and endometriotic tissue. Its expression was significantly higher in secretory than in proliferative phase endometrium. It was low but detectablein 13 of 16 proliferative phase biopsies. The majority of these endometriaexhibited both glandular and stromal staining (63%). In the secretory phase, glandular cells exhibited a significantly greater intensity of staining compared to stromal cells. In endometriotic tissue, stromal cell CD44s expression did not differ between tissue types in either stage of the cycle. Incontrast, glandular expression in endometriotic tissue during the secretory phase was reduced (p < 0.05) compared to eutopic endometrium. It was absent in 66% of cases and reduced in the remaining cases. Our results indicatea correlation between CD44s expression and secretory differentiation of endometrial glands in the cycle, suggesting hormonal regulation of its expression. This cyclic pattern of CD44s expression was lost in corresponding endometriotic tissue. Reduced expression of CD44s in endometriotic tissue may provide insight into the pathophysiology of endometriosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:34:07