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Titolo:
Epidemiologic and mucosal immunologic aspects of HPV infection and HPV-related cervical neoplasia in the lower female genital tract: A review
Autore:
Tjiong, MY; Out, TA; Ter Schegget, J; Burger, MPM; Van der Vange, N;
Indirizzi:
Netherlands Canc Inst, Dept Gynecol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Dept Virol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Clin & Lab Immunol Unit, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Dept Obstet & Gynecol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, CLB, Sanquin Blood Supply Fdn, Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands Fdn, Amsterdam, Netherlands
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
fascicolo: 1, volume: 11, anno: 2001,
pagine: 9 - 17
SICI:
1048-891X(200101/02)11:1<9:EAMIAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PAPILLOMAVIRUS TYPE-16; VIRUS-LIKE PARTICLES; HUMAN-IMMUNODEFICIENCY-VIRUS; CARCINOMA CELL-LINES; WARTS CONDYLOMATA-ACUMINATA; LINKED-IMMUNOSORBENT-ASSAY; ORAL-CONTRACEPTIVE USE; INTRAEPITHELIAL NEOPLASIA; RISK-FACTORS; LANGERHANS CELLS;
Keywords:
cervical neoplasia; HPV; mucosal immunology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Van der Vange, N Netherlands Canc Inst, Dept Gynecol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Plesmanlaan 121 Amsterdam Netherlands NL-1066 CX
Citazione:
M.Y. Tjiong et al., "Epidemiologic and mucosal immunologic aspects of HPV infection and HPV-related cervical neoplasia in the lower female genital tract: A review", INT J GYN C, 11(1), 2001, pp. 9-17

Abstract

Human papillomavirus (HPV) infections are known to play an important role in the pathogenesis of cervical neoplasia. Considering the morbidity and mortality of cervical cancer, infection with HPV can be regarded as a worldwide problem, especially in developing countries. Currently, many studies focus on the development of both prophylactic and therapeutic HPV vaccines. Crucial for these vaccination protocols to be successful is that they will result in a long-lasting ability to generate an immune response that will eliminate the virus. HPV transmission and subsequent infection is a local event in the lower female genital tract and therefore the efficacy of vaccines against this locally transmitted infection can be best assessed by parameters of local immunity. In this review we describe both the epidemiology of HPV-related cervical neoplasia and the general aspects of mucosal immunity in the female genital tract while focusing on the local humoral immunity in HPV-related cervical neoplasia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:56:14