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Titolo:
Nodal signaling and the zebrafish organizer
Autore:
Schier, AF; Talbot, WS;
Indirizzi:
NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol,Dev Genet Program, New York, NY 10016 USA NYU New York NY USA 10016 Biol,Dev Genet Program, New York, NY 10016 USA Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Biol, Sch Med, Stanford, CA 94305 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 45, anno: 2001,
pagine: 289 - 297
SICI:
0214-6282(2001)45:1<289:NSATZO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONE-EYED PINHEAD; DORSOVENTRAL PATTERN-FORMATION; MUTATIONS AFFECTING DEVELOPMENT; CENTRAL-NERVOUS-SYSTEM; YOLK SYNCYTIAL LAYER; HOMEOBOX GENE; DANIO-RERIO; FLOOR-PLATE; NO TAIL; ANTERIOR NEUROECTODERM;
Keywords:
Zebrafish; nodal; EGF-CFC; lefty; bozozok; shield;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Schier, AF NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol,Dev Genet Program, New York, NY 10016 USA NYU New York NY USA 10016 enet Program, New York, NY 10016 USA
Citazione:
A.F. Schier e W.S. Talbot, "Nodal signaling and the zebrafish organizer", INT J DEV B, 45(1), 2001, pp. 289-297

Abstract

Systematic genetic screens in zebrafish have led to the discovery of mutations that affect organizer function and development. The molecular isolation and phenotypic analysis of the affected genes have revealed that TGF-betasignals of the Nodal family play a key role in organizer formation. The activity of the Nodal signals Cyclops and Squint is regulated extracellularlyby the EGF-CFC cofactor One-eyed Pinhead and by antagonists belonging to the Lefty family of TGF-beta molecules. In the absence of Nodal signaling, the fate of cells in the organizer is transformed from dorsal mesoderm to neural ectoderm. Differential Nodal signaling also patterns the organizer along the anterior-posterior axis, with high levels required for anterior cellfates and lower levels for posterior fates. In addition, Nodal signaling cooperates with the homeodomain transcription factor Bozozok in organizer formation and neural patterning. The combination of genetic, molecular and embryological approaches in zebrafish has thus provided a framework to understand the mechanisms underlying organizer development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:23:39